G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-beta in Alzheimer’s disease. Mol. Biomed. 2, 17 (2021). Article PubMed PubMed Central Google Scholar Rai, S. N. et al. The role of PI3K/Akt and ERK in neurodegenerative disorders. ...
G protein-coupled receptor-targeting antibody-drug conjugates: current status and future directions. Cancer Lett. 2023;564:216191. https://doi.org/10.1016/j.canlet.2023.216191. Article CAS PubMed PubMed Central Google Scholar Razzaghdoust A, Rahmatizadeh S, Mofid B, Muhammadnejad S, Parvin...
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A novel member of the G protein-coupled receptor (GPCR) family was cloned and characterized, which is unique, among the members, in its long extracellular domain comprising Ig-like repeats and in its high expression predominantly in the lung. The clone (Ig-Hepta) was first identified as a ...
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This demonstrates that cannabinoid receptor expression modifies posttranslational processing of the FLAG-hD2 receptor, and importantly, has wider implications for the utilisation and interpretation of receptor studies involving epitope tags. G protein-coupled receptors (GPCRs) are a large family of ...
G protein-coupled receptors: novel targets for drug discovery in cancer. Nat Rev Drug Discov 2011; 10:47-60. 21 Mayne M, Shepel PN, Jiang Y, Geiger JD, Power C. Dysregu- lation of adenosine A1 receptor-mediated cytokine expression in peripheral blood mononuclear cells from multiple ...
These proteins precisely transduce extracellular signals from the ligand-activated G-protein-coupled recep- tors (GPCR) to the downstream effectors. In vertebrates, G-proteins are involved in the recognition and transduction of diverse signals such as light, calcium, odorants, small molecules, and ...
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Upon binding glutamate, the metabotropic glutamate receptor mGluR6 activates the heterotrimeric G-protein Gαoβ3γ13, and this leads to closure of the TRPM1 channel (melastatin). TRPM1 is thought to be constitutively open, but the mechanism that leads to its closure is unclear. We ...