G 蛋白偶联受体(G Protein-Coupled Receptors, GPCRs)是一 类在生物体内广泛存在的膜蛋白,它们负责接收细胞外的信号并将其 转化为细胞内的响应,从而调控众多生理和病理过程。自上世纪70 年代发现第一个GPCR 以来,关于这类受体的研究一直备受关注,并 在药物研发、疾病治疗等领域展现出巨大的潜力。本文旨在全面概述 ...
《细胞生物学》英文版第15章信号转导与G蛋白-偶联受体.ppt,Key Concepts No.4 Glycogen metabolism is regulated by hormone -induced activation of protein kinase A. 15.5 G protein-Coupled Receptors (GPCRs): that activate or inhibit Adenylyl Cyclase Figure 15.31
G蛋白介导的信号转导 ➢GPCR➢G蛋白介导的跨膜信号转导➢小G蛋白 GPCR的分子结构 ➢又称蛇型受体(serpentinereceptor),只存在与真核生物中。➢通常由单一的多肽链或均一的亚基组成：跨膜区由7个螺旋结构组 成；每个疏水跨膜区段由20-25个氨基酸组成，多肽链的N-端位于细胞外区，而C-端位于细胞内区...
Overexpression of G protein-coupled receptors in cancer cells: involvement in tumor progression. Int. J. Oncol. 27, 1329–1339 (2005). CAS PubMed Google Scholar Lui, V. W. et al. Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by ...
of G protein-coupled receptors and the structural features that are responsible for the various functions ascribed to cell-surface receptors, particularly it emphasizes on the 尾-adrenergic receptor, because it, along with rhodopsin, is the most extensively studied of the G protein-coupled receptors....
G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and an important class of drug targets, play a role in maintaining numerous physiological processes. Agonist or antagonist, orthosteric effects or allosteric effects, and biased signaling or balanced signaling, characteri...
G protein-coupled receptors (GPCRs) are unique integral membrane proteins comprising seven transmembrane helical regions with an N-terminal region (extracellular), a C-terminal region (cytosolic), and three loops on each of the interior and exterior faces of the cell membrane. ...
G protein-coupled receptors (GPCRs) have experienced a transformationfrom random ligand screening to knowledge-driven drug design. We are eye-witnessing tremendous progresses made recently inthe understanding of their structure–function relationships that facilitated drug development at an unprecedented pace...
《G Protein-Coupled Receptors in Health and Disease》是2009年出版的 图书，作者是Tao, Ya-Xiong 。内容简介 G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. ...