Protein EngineeringSignal TransductionModels, MolecularDifferent families of G-protein-coupled receptors (GPCRs) have been engineered to provide exclusive control over the activation of these receptors and thus to understand better the consequences of their signaling in vitro and in vivo. These engineered...
gpcrdb: contains data, diagrams and web tools for G protein-coupled receptors (GPCRs). Users can browse all GPCR structures and the largest collections of receptor mutants. Diagrams can be produced and downloaded to illustrate receptor residues (snake-plot and helix box diagrams) and relationships...
Biosignaling G-protein-coupled Receptors cAMP & Adenylate Cyclase 15:15 Biosignaling G-protein-coupled Receptors PLC, DAG, & IP3 07:34 Biosignaling Janus KinasesThe JAK-STAT Pathway 05:19 Biosignaling NotchDelta Signaling Pathway 06:38 Biosignaling Receptor Desensitization by Beta-arrestin 10:16 ...
–Application examples of GPCR (G-protein coupled receptors ) binding measurement with small molecules and antibodies. REGISTER Applications of Cell-based SPR Microscopy with AstraZeneca Drug Target Review webinar (June 30 2020) Speakers: Dr. Niklas Larsson, Associate Prinicipal Scientist, Astra...
100 µg • Murine SCF, 100 µg • Murine TPO, 100 µg • Murine IL-6, 10 µg 2024 product list thermofisher.com/peprotech 5 Animal-free cytokines Gibco™ PeproTech™ animal-free cytokines are designed to minimize potential variables associated with the use of animal-derive...
Key words: sleep deprivation; heart failure; atrial fibrillation; G protein-coupled receptor kinase 2 (GRK2) [more] Organism: Rat Tissue: Heart 121 Unveiling the role of TAGLN2 in glioblastoma: From proneural-mesenchymal transition to Temozolomide resistance Y Li, X Wang, T Xu, F Xu, T...
Overview of various steps and tools for data analysis of single cell transcriptomics (scRNA-seq), chromatin accessibility (scATAC-seq), surface protein (CITE-seq), antigen immune receptor repertoire (AIRR, TCR and BCR profiling), and spatial transcriptomics. QC, doublet removal (scDoubletFinder)...
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Experience with GILENYA in patients receiving concurrent therapy with drugs that slow the heart rate or AV conduction (e.g., beta blockers, digoxin, or heart rate-slowing calcium channel blockers, such as diltiazem or verapamil) is limited. Because initiation of GILENYA treatment may result in ...
to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinae...