这些信使被蛋白激酶识别,从而导致其活化并触发朝向细胞事件的信号级联。 G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in eukaryotes. G proteins are specialized proteins with the ability to bind the nucleotides guanosine triphosphate (GTP) and guanosine ...
近日,来自宁夏医科大学的研究者们在Signal Transduction and Targeted Therapy杂志上发表了题为“G protein-coupled receptors (GPCRs): advances in structures,mechanisms, and drug discovery”的综述性文章,该研究揭示了G蛋白偶联受体的结构、机制和药物发现的进展。 G蛋白偶联受体(gpcr)是最大的人膜蛋白家族,也是一...
G protein–coupled receptors (GPCRs) are implicated in nearly allphysiological processesin the human body and represent an importantdrug targetingclass. The genes encoding the different GPCR (sub)types determine their specific functionality, which can be altered by naturalgeneticvariants andisoform...
《G Protein-Coupled Receptors》是2010年出版的图书，作者是 Poyner, David R.; Wheatley, Mark。内容简介 G-Protein Coupled Receptors (GPCRs) are not only the largest protein family in the human genome but are also the single biggest target for therapeutic agents. Research into GPCRs is therefore ...
G protein-coupled receptors (GPCRs) are critical cellular sensors that mediate numerous physiological processes. In the heart, multiple GPCRs are expressed on various cell types, where they coordinate to regulate cardiac function by modulating critical processes such as contractility and blood flow. Un...
G protein-coupled receptors are considered the most widely investigated drug discovery targets. They are the largest family of receptors with almost 800 genes in humans. Different types of ligands can activate these receptors, such as catecholamines, nucleotides, lipids, and gut microbio...
近日,来自宁夏医科大学的研究者们在Signal Transduction and Targeted Therapy杂志上发表了题为“G protein-coupled receptors (GPCRs): advances in structures,mechanisms, and drug discovery”的综述性文章,该研究揭示了G蛋白偶联受体的结构、机制和药物发现的进展。
Ahren, B. Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes. Nature Rev. Drug. Discov. 8, 369–385 (2009). This is an excellent review on the role of GPCRs in the regulation of pancreatic β -cells and their established or potential roles as targets...
《G Protein-Coupled Receptors in Health and Disease》是2009年出版的 图书，作者是Tao, Ya-Xiong 。内容简介 G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. ...
EC, extracellular side; GPCR, G protein–coupled receptor; IC, intracellular side; PDB, Protein Data Bank; SNVs, single-nucleotide variants. Drug candidates targeting LT receptors A recent analysis of 1000 drug discovery campaigns revealed a lower attrition rate and a higher probability of reaching...