Inconsistent conclusions have been drawn regarding the phylogenetic age of the Methuselah/Methuselah-like (Mth/Mthl) gene family of G protein-coupled receptors, the founding member of which regulates development and lifespan in Drosophila. Here we report
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► Osmoregulated HE6 receptor arose species-specific duplication in T. castaneum. ► mthl largely expanded in D. melanogaster likely due to adaptive evolution. Introduction G protein-coupled receptors (GPCRs) are one of the largest protein super-families and function in the cell membrane. They...
G-protein coupled receptors (GPCRs) are ancient, ubiquitous, constitute the largest family of transducing cell surface proteins, and are integral to cell communication via an array of ligands/neuropeptides. Molt inhibiting hormone (MIH) is a key neuropep
the germline cells eliminated the capability of males to increase their GSC division frequency when mated. These were the Serotonin (5-HT) Receptors 1 A, 1B and 7, Methuselah (Mth), Methuselah-like5 (Mth-l5), Octopamineβ2-Receptor (Octβ2R), and a predicted GPCR encoded byCG12290....
Introduction G protein signaling is a universal means of signal transduction in living organisms, activating many G protein coupled receptor (GPCR) mediated cellular processes. The G protein signaling pathway consists of a series of components. External signals are transmitted to target genes via GPCR...