5. Cao C, Huang X, Han Y, Wan Y, Birnbaumer L, Feng GS, Marshall J, Jiang M, Chu WM: Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the Akt-mTORC1 pathway. Sci Signal 2009, 2:ra17.6. Liu YY, Chen MB, Cheng L, Zhang ZQ, Yu Z...
5. Cao C, Huang X, Han Y, Wan Y, Birnbaumer L, Feng GS, Marshall J, Jiang M, Chu WM: Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the Akt-mTORC1 pathway.Sci Signal2009, ...
Tang et al., showed that Ginseng Rh2 protected endometrial cells from OGD/R-induced oxidative injury via blocking CypD-dependent programmed necrosis pathway [55]. Xu et al., reported that microRNA-1203 silenced CypD to protect endometrial cells from OGD/R-induced programmed necrosis [67]. In ...
并通过体内质谱分析及体外模拟实验,成功揭示了“胶原GXXGER-整合素α亚基I结构域”复合体形成以及“Rhoa/ROCK1”通路在Opticin抑制新生血管过程中的重要作用(图二),
stimulation of Gαq/11 promotes sustained mTORC1 pathway activation and reversion of autophagy promoted by serum or amino acids removal. Gαq is present in autophagic compartments and lysosomes and is part of the mTORC1 multi-molecular complex, contributing to its assembly and activation via its ...
ROCK1Signaling”(通讯作者为马进教授,博士研究生刘小雪和邢悦为共同第一作者)、“Erianin controls collagen-mediated retinal angiogenesis via the RhoA/ROCK1 signaling pathway induced by the alpha2/beta1 integrin-collagen interactio...
GLP-1R - cAMP signalling pathway in pancreatic beta cells. 另外一个可以激活 G_{as} 亚基的G蛋白耦联受体是TGR5——一种在肝脏具有高表达的胆汁酸受体。下图[4]中,TGR5与配体结合可以促进小肠内脂肪的吸收,且此机理受腺嘌呤环化酶/cAMP信号通路下调。 TGR5 signaling pathway via cAMP. G_{\alpha q/11}...
5’-adenosine monophosphate (cAMP) concentration through Gαs coupling, but interestingly, β2AR antagonists are able to effectively inhibit fibroblast-like synoviocytes (FLSs) proliferation, thus ameliorating experimental RA, indicating that the β2AR signalling pathway is impaired in RA FLSs via ...
[1]. in vitro: Kaempferol was found to inhibit estrogen receptor alpha expression in breast cancer cells and to induce apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Studies have shown that kaempferol also has anti-inflammatory effects via inhibition of interleukin...
alpha subunit of Gq. Immunohistochemical staining with commercially obtained anti-human Gα11antibody, of which specific reactivity to the alpha subunit ofLimaxGq (limGαq) was confirmed (Additional file2: Fig. S2a-c), showed the presence of limGαqin the rhabdomere of Type-I photoreceptors...