Extravasation of Leukocytes from Circulation is Controlled by Gαi2 Signaling Events in the EndotheliumCircuit SatisfiabilityBoolean SatisfiabilityCircuit Delay ComputationTest Pattern GenerationBoolean satisfiability is a ubiquitous modeling tool in Electronic Design Automation (EDA). It finds application in ...
Simultaneous quantitative determination of alpha-ketoglutaric acid and 5-hydroxymethylfurfural in human plasma by gas chromatography-mass spectrometry. Anal. Bioanal. Chem. 396, 2629–2637 (2010). CAS PubMed Google Scholar Ahmadian, M., Wang, Y. & Sul, H. S. Lipolysis in adipocytes. Int. J...
VE-cadherin is a member of the cadherin superfamily that is located in a six-cadherin cluster in a region on the long arm of chromosome 16 and is involved in loss of heterozygosity events in breast and prostate cancer. VE-cadherin protein is a calcium-dependent cell-cell adhesion glycoprotein...
Similar to other kinases, CDKs have a bi-lobed structure, consisting of a beta amino and an alpha carboxyl subunits [27, 29]. The active site of CDKs is sandwiched between these two subunits [29, 30]. The centrally located core of the CDKs consists of an ATP-binding pocket and a ...
VE-cadherin is a member of the cadherin superfamily that is located in a six-cadherin cluster in a region on the long arm of chromosome 16 and is involved in loss of heterozygosity events in breast and prostate cancer. VE-cadherin protein is a calcium-dependent cell-cel...
The mTORC1 node plays a major role in autophagy modulation. We report a role of the ubiquitous Gαq subunit, a known transducer of plasma membrane G protein-coupled receptors signaling, as a core modulator of mTORC1 and autophagy. Cells lacking Gαq/11 d
Activation of integrins in response to inside-out signaling serves as a basis for leukocyte arrest on endothelium, and migration of immune cells. Integrin-dependent adhesion is controlled by the conformational state of the molecule (i.e. change in the af
RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled ...
Krystofova S, Borkovich KA: The heterotrimeric G-protein subunits GNG-1 and GNB-1 form a Gβγ dimer required for normal female fertility, asexual development, and galpha protein levels in Neurospora crassa. Eukaryotic Cell. 2005, 4: 365-378. 10.1128/EC.4.2.365-378.2005. Article PubMed ...
8Due to the distinct topography between the binding sites of extracellular stimuli and the subsequent signaling events at the intracellular site (approximately 40 Å), GPCR signal transduction is allosteric.9,10,11,12,13Advances in protein engineering, X-ray crystallography, and cryo-electron ...