discoideum to binding sites on the inner face of the plasma membrane reflects activation of the G protein–linked signaling system. Increments in chemoattractant elicit a uniform response around the cell periphery. Yet when cells are exposed to a gradient, the activation occurs selectively at the ...
Furthermore, use of bacterial toxins such as pertussis that lead to ADP-ribosylation of the G-protein alpha subunits of Go and G[sub i2] do not block the increase in IP[sub 3] levels but U-73122, a PLC inhibitor, blocks the production of IP[sub 3]. Studies with monospecific ...
studying G-protein signaling in animals lacking their function throughout the whole body could affect behavior and physiology of the fly, leading to confounding effects on mating and GSC divisions. Fortunately, large collections of RNA-i-lines are available...
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Remarkably, AMG-treated cells showed increased cell migration (Fig. 2f) and enhanced expression of the myofibroblast marker alpha-Smooth Muscle Actin (ɑ-SMA) by immunostaining and western blotting analysis (Figs. 2g, h, S3B). Fig. 2 AMG treatment increases migration capacity of murine primary ...
Offermanns, S., and Simon, M.I., 1995 Jun, "G alpha 15 and G alpha 16 Couple a Wide Variety of Receptors to Phospholipase C," J Biol Chem, 170(25):15175-15180. Offermanns, S., et al., 1997 Sep, "Defective platelet activation in G.alpha. .sub.g -deficient mice," Nature,...
The signaling events mediated by c-Met and the subsequent biological effects of hepatocyte growth factor (HGF)3 have been shown to be important in many key cellular functions as follows: epithelial-mesenchymal interactions; the regulation of cell migration, invasion, proliferation, and survival; ...
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the ...
Gundersen et al., "Neural Regulation of Muscel Acetylcholine Receptor .epsilon.-and .alpha.-Subunit Gene Promoters in Transgenic Mice," J. Cell Biol., 123(6):1535-1544 (1993). Heinflink et al., "A Constitutively Active Mutant Thyrotropin-Releasing Hormone Receptor Is Chronically Down-Regulated...
Role of oxidative stress and Ca(2+) signaling in psychiatric disorders. Front. Cell Dev. Biol. 9, 615569 (2021). Article PubMed PubMed Central Google Scholar Dutt, P., Nguyen, N. & Toksoz, D. Role of Lbc RhoGEF in Galpha12/13-induced signals to Rho GTPase. Cell. Signal. 16,...