SARS-CoV-2COVID-19microRNAbiomarkerstherapeutic targetsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, a pandemic associated with substantial morbidity and mortality. Despite of this, no vaccine or approved drug is available to eradicate the virus. In this...
SARS-CoV-2 This article is cited by Use of phase plate cryo-EM reveals conformation diversity of therapeutic IgG with 50 kDa Fab fragment resolved below 6 Å Hsin-Hung Lin Chun-Hsiung Wang Wei-Hau Chang Scientific Reports(2024) Virion morphology and on-virus spike protein structures of diver...
SARS-CoV-2 infection causes acute lung injury by impairing airway epithelial barrier function. We thus initially examined the effects of SARS-CoV-2 E protein on airway epithelial integrity. The confluent monolayers of human airway epithelial cells were apically treated with E protein at Day 9, wh...
Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. N Engl J Med. 2020;382(16):1564-1567. doi:10.1056/NEJMc2004973 PubMedGoogle ScholarCrossref 7. Feng S, Shen C, Xia N, Song W, Fan M, Cowling BJ. Rational use of face masks...
In contrast, mAbs approved for the control of chronic inflammatory and autoimmune pathologies directly target key inflammatory pathways, such as tumor necrosis factor α (TNF-α), interleukins, and interleukin receptors. Likewise, mAbs against infectious diseases, such as respiratory syncytial virus (...
President of the British Medical Association Dear Professor Gillon, why is SARS-CoV-2 such a major problem, given that other coronaviruses are regarded as common colds? Is it possible that ‘gain of function’ research has been undertaken on this virus?
and a previous review has summarised the function of S-palmitoylation on key molecules of the innate immune response in infectious diseases.10Using the S-palmitoylation regulation of SARS-CoV-2 proteins as an example, we will briefly explore its role in the viral infection process. SARS-CoV-2 ...
The responsible virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily affects the lungs, but it has multisystemic effects. It is well known that dysfunction of multiple endocrine organs may occur during or after COVID-19. Impairment of the hypothalamic-pituitary-adrenal (...
Integrated correlative light and electron microscopy (CLEM) combines the study of the ultrastructure and cellular dynamics of virus-infected cells and can be efficiently used for screening samples at low and high resolution. Learn more how integrated CLE
Although most studies of SARS-CoV-2 immunity have focused on the humoral immune response, emerging data suggest that T cell-mediated immunity is also likely to play an important role in eliminating the virus. Lymphopenia, characterized by reduced numbers of CD4+ and CD8+ T cells, is predictive...