Cancer cells are under chronic endoplasmic reticulum (ER) stress due to hypoxia, low levels of nutrients, and a high metabolic demand for proliferation. To survive, they constitutively activate the unfolded protein response (UPR). The inositol-requiring protein 1 (IRE1) and protein kinase RNA-lik...
Interleukin (IL)-23 is a heterodimeric cytokine closely related to IL-12. Yet, despite a strong structural relationship that includes a shared p40 subunit,... BS Mckenzie,RA Kastelein,DJ Cua - 《Trends in Immunology》 被引量: 0发表: 2006年 The cytoplasmic tail of the human respiratory sync...
The predominant type of immune cell in the brain is the microglia, a type of tissue-resident macrophage. In a variety of neurodegenerative settings, microglia alter their transcriptional profile, morphology and function in similar ways; thus, these activ
Since these auto-regulatory T cells express IL-2Rβ (CD122), we hypothesized that their development might also be regulated by IL-2. Here, we investigate the effects of differences in IL-2 expression on this autoregulatory subset. We show that decreased IL-2 production impairs the regulatory...
Condoms effectively prevent against HIV, especially when used in conjunction with biomedical strategies such as PrEP and viral suppression. However, consistent use of condoms in the real world has been a continual health promotion challenge, even among populations at highest risk, such as young men...
Correlation of in vitro CD4+ T helper cell function with clinical graft status in immunosuppressed kidney transplant recipients. We recently identified three distinct T helper pathways which contribute to interleukin-2 (IL-2) production by human peripheral blood lymphocytes following... S C,Muluk,Cler...
High Rab3C expression levels promote tumor metastasis, which is associated with poor prognosis in CRC by modulating the secretion of IL-6 through exocytosis and activating the JAK2-STAT3 signaling pathway (Chang et al.2017). Furthermore, Ruxolitinib, a JAK2-specific inhibitor, is demonstrated to ...
Lipopolysaccharide-stimulated transcriptions of IL-1 and IL-12 p40 in RAW264 were inhibited by -carotene but not by ±-tocopherol. These results indicate that -carotene, which can modulate the intracellular redox status of macrophages by enhancing the level of intracellular glutathione, is related ...
TET2 loss-of-function mutations are one of the most common mutations in CHIP, present in approximately one-third of cases2. Tet2-deficient murine HSPCs are shown to have increased self-renewal potential6. Studies have identified inflammatory cytokines, including IL1β, IL6, and TNFα, are elev...
Inhibition of IκKα/β with a novel selective inhibitor reproduced the impaired monocyte phenotype with decreased production of TNF-α, IL-6, IL-12p70, IL-10, GM-CSF, VEGF, MIP-1β, TNF-β, IFN-α2 and IL-7 in response to an LPS challenge. Surgical patients with infection also ...