IL-1beta promotes the age-associated decline of beta cell functionCell biologyCellular physiologyPhysiologyAging is the prime risk factor for the development of type 2 diabetes. We investigated the role of the interleukin-1 (IL-1) system on insulin secretion in aged mice. During aging, ...
DomainThe similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function. Cellular localizationSecreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by...
Warning: Invalid argument supplied for foreach() in /home/prospec/public_html/cart/Smarty-2.5.0/plugins/function.interpro.php on line 30 Gene: Name:Il1b Protein synonyms/aliases: Interleukin-1 beta precursor (IL-1 beta). Protein Family: Belongs to the IL-1 family. ...
Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase. J Exp Med 1995;181:... Corbett,A J. - 《Journal of Experimental Medicine》 被引量: 388发表: 1995年 Double-stranded RNA inhibits beta-cell function and induces ...
Long Name Interleukin 1 beta Entrez Gene IDs 3553 (Human); 16176 (Mouse); 24494 (Rat); 397122 (Porcine); 403974 (Canine); 100034237 (Equine); 100135556 (Guinea Pig) Alternate Names catabolin; IL1 beta; IL-1 beta; IL-1; IL1B; IL-1b; IL1-BETA; IL-1F2; IL1F2IL-1 beta; inte...
Function IL-1β is a cytokine with a key role in the pathophysiology of local and systemic inflammation. IL-1β induces cytokine, chemokine, proinflammatory molecule secretion, and adhesion molecule expression in diverse cells. IL-1β is induced by high concentrations of glucose, free fatty acid...
用途:Insulin, recombinant human (rHu) is identical in function and structure to the native human sequence. A hormone consisting of two polypeptide chains, rHu Insulin′s A-chain (21 amino acids) and B-chain (30 amino acids) are covalently linked by disulfide bonds between cysteine residues. ...
a血管平滑肌细胞表达炎症因子IL-1α和β的基因,并以自分泌的形式分泌IL-1来调控细胞功能 Blood vessel smooth muscle cell expression inflammation factor IL-1α and beta the gene, and by secretes IL-1 from the secretion form to regulate the cell function[translate]...
Activation of the inflammatory response system and varied levels of cytokines in acute schizophrenia have been suggested by recent studies. Psychopharmacologic agents can differentially effect cytokine production, which suggests that therapeutic function of neuroleptics may involve immunomodulation. The present...
Transient overexpression of TRAIL R4 in cells normally sensitive to TRAIL-mediated killing confers completeprotection, suggesting that one function of TRAIL R4 may be inhibition of TRAIL cytotoxicity.Ig TypeRabbit IgG