In this article, we have shown that IL-1 beta is a key molecule that can orchestrate both Toll-like receptor and muscarinic receptor pathways, and that antagonizing the function of IL-1 beta has a promising future as a potential drug target for asthma treatment. IL-1 beta can activate NF...
a血管平滑肌细胞表达炎症因子IL-1α和β的基因,并以自分泌的形式分泌IL-1来调控细胞功能 Blood vessel smooth muscle cell expression inflammation factor IL-1α and beta the gene, and by secretes IL-1 from the secretion form to regulate the cell function[translate]...
Protein Function: IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 21% amino acid (aa) identity in ...
In this article, we have shown that IL-1 beta is a key molecule that can orchestrate both Toll-like receptor and muscarinic receptor pathways, and that antagonizing the function of IL-1 beta has a promising future as a potential drug target for asthma treatment. IL-1 beta can activate NF...
TRAIL R4 retains a C-terminal element containing one third of aconsensus death domain motif. Transient overexpression of TRAIL R4 in cells normally sensitive to TRAIL-mediated killing confers completeprotection, suggesting that one function of TRAIL R4 may be inhibition of TRAIL cytotoxicity. 展开 ...
Top of pageResults Discussion Experimental procedures Acknowledgements References Growth factors, including fibroblast growth factor-2 (FGF-2) and transforming growth factor-β (TGF-β) regulate fibroblast function, differentiation and proliferation. S100A8 and S100A9 are members of the S100 family of Ca...
FunctionPotent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes ...
Long Name Interleukin 1 beta Entrez Gene IDs 3553 (Human); 16176 (Mouse); 24494 (Rat); 397122 (Porcine); 403974 (Canine); 100034237 (Equine); 100135556 (Guinea Pig) Alternate Names catabolin; IL1 beta; IL-1 beta; IL-1; IL1B; IL-1b; IL1-BETA; IL-1F2; IL1F2IL-1 beta; inte...
Interleukin-1 is a potent pro inflammatory agent, has a direct influence on human thyroid cell function, and modulates cell growth in differentiated thyroid carcinoma cell lines. To evaluate whether a polymorphism on the IL-1beta gene has an influence on the incidence of thyroid disorders, we an...
Transient overexpression of TRAIL R4 in cells normally sensitive to TRAIL-mediated killing confers completeprotection, suggesting that one function of TRAIL R4 may be inhibition of TRAIL cytotoxicity.Ig TypeRabbit IgG