IL-1beta blockade reduced proliferation of effector T cells by induction of suppressive function of iTregs in both JIA (suppression from 55.1% to 34.2% proliferating effectors) and HC (from 48.2% to 31.8%) (p<0.001). Intracellular IL-10 production was not influenced by blockade of IL-1beta...
Examines the effects of human interleukin-1beta (IL-1beta) on the function of the beta-adrenergic receptor (betaAR)-adenylyl cyclase (AC) system in a human airway epithelial cell line. Effects of IL-1beta on betaAR density; Effects of IL-1beta on beta2AR messenger RNA; Effects of IL-...
Association of IL-1 and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers. Thorax 2001;56:863-6.Joos L, McIntyre L, Ruan J, Connett JE, Anthonisen NR, Weir TD et al. Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of...
Investigates the pathogenic function of interleukin (IL)-1Beta in psoriasiform skin lesions of the spontaneous mouse mutation flaky skin. Impact of the inhibition of IL-1Beta; Suggestion of differential response among various cutaneous cell types; Inefficacy of cyclosporin A as treatment of psoriasis...
Potential role of protein kinase CK2 in IL-1beta-induced epithelial cell functionThe mechanisms underlying chronic intestinal inflammation in inflammatory bowel disease (IBD) are unknown; however, activation of the transcription factor NF kappa B appears to be a consistent feature and the target for ...
SC, Brosnan CF (2005) The cytokine IL-1beta transiently enhances P2X7 receptor expression and function in human astrocytes. Glia 49:245–258 - Narcisse, Scemes, et al.Narcisse L,Scemes E,Zhao Y,et al.The cytokine IL-1beta transiently enhances P2X7 receptor expression and functio...
Xiap-/- mice responded to intranasal application of the virus with systemic hyper-inflammation exemplified by elevated IL-1beta levels, splenomegaly and increased activation of peripheral T lymphocytes such as CD4+ effector T cells, regulatory T cells (Treg), and IFNg+ T cells. In previous work...
Disclosed are methods for improvement of beta cell function in a subject using an anti-IL-1β antibody or fragment thereof.doi:US8377429 B2Patrick J. ScannonAlan M. SolingerRobert J. BauerUSFeb 19, 2013
A2E Suppresses Regulatory Function of RPE Cells in Th1 Cell Differentiation Via Production of IL-1beta and Inhibition of PGE2. Investig. Ophthalmol. Vis. Sci. 2015, 56, 7728-7738. [CrossRef]Shi Q, Wang Q, Li J, et al. A2E Suppresses regulatory function of RPE cells in Th1 cell ...
An IL-15 superagonist/IL-15Ralpha fusion complex protects and rescues NK cell- cytotoxic function from TGF-beta1-mediated immunosuppression. Cancer Immunol Immunother. 2018;67(4):675-89.Fujii, R.; Jochems, C.; Tritsch, S.R.; Wong, H.C.; Schlom, J.; Hodge, J.W. An il-15 ...