Craft1, Serena L. M. Craft1 & Cuong Q. Nguyen1,2 Interleukin (IL)-17 is one of the critical inflammatory cytokines that plays a direct role in development of Sjögren's syndrome (SjS), a systemic autoimmune disease characterized by a progressive chronic attack against the ...
Inhibition of IκKα/β with a novel selective inhibitor reproduced the impaired monocyte phenotype with decreased production of TNF-α, IL-6, IL-12p70, IL-10, GM-CSF, VEGF, MIP-1β, TNF-β, IFN-α2 and IL-7 in response to an LPS challenge. Surgical patients with infection also ...
Interleukin (IL)-23 is a heterodimeric cytokine closely related to IL-12. Yet, despite a strong structural relationship that includes a shared p40 subunit,... BS Mckenzie,RA Kastelein,DJ Cua - 《Trends in Immunology》 被引量: 0发表: 2006年 The cytoplasmic tail of the human respiratory sync...
Sustained intratumoral delivery of IL-12 and GM-CSF can overcome tumor immune suppression and promote T cell-dependent eradication of established disease in murine tumor models. However, the antitumor effector response is transient and rapidly followed by a T suppressor cell rebound. The mechanisms th...
(M = 22.9 years) living in Chicago, IL (19.2% living with HIV). Using multivariable logistic regression, we examined longitudinal associations between condom-associated sexual functioning (erectile function, orgasm satisfaction, global satisfaction, and anal discomfort) and condomless insertive anal...
High Rab3C expression levels promote tumor metastasis, which is associated with poor prognosis in CRC by modulating the secretion of IL-6 through exocytosis and activating the JAK2-STAT3 signaling pathway (Chang et al.2017). Furthermore, Ruxolitinib, a JAK2-specific inhibitor, is demonstrated to ...
Since these auto-regulatory T cells express IL-2Rβ (CD122), we hypothesized that their development might also be regulated by IL-2. Here, we investigate the effects of differences in IL-2 expression on this autoregulatory subset. We show that decreased IL-2 production impairs the regulatory...
In addition, immune checkpoint molecules including cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), programmed cell death-ligand 1 (PD-L1), and programmed cell death-1 (PD-1), immunosuppressive cytokines including interleukin (IL)-10 and IL-8, and exosomes are critical in the TIME [84]...
A study indicating that MSC-derived CAFs promote inflammation-induced gastric cancer progression and are characterized by global DNA hypomethylation and elevated expression of IL-6, WNT5A and bone morphogenetic protein 4 (BMP4). CAS PubMed PubMed Central Google Scholar Xu, J. et al. ...
This work uses the model of Batf3 deficiency to confirm early reports of cDC1s as a source of IL-12 during innate immune responses in mice. Article CAS PubMed PubMed Central Google Scholar Askenase, M. H. et al. Bone-marrow-resident NK cells prime monocytes for regulatory function ...