IL-23: changing the verdict on IL-12 function in inflammation and autoimmunity. Expert. Opin. Ther. Tar- gets 9: 1123-1136.Kreymborg K,Bohlmann U,Becher B.IL-23:changing the ver-dict on IL-12function in inflammation and autoimmunity. Expert Opin...
[1] Chiossone, Laura et al. “Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells.” Blood vol.[2] 李焱,叶敬伟,郭晓玲.IL-12、IL-15对急性髓系白血病患者骨髓来源CD34+白血病细胞转化...
参考文献 [1]Chiossone, Laura et al. “Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells.” Blood vol. [2]李焱,叶敬伟,郭晓玲.IL-12、IL-15对急性髓系白血病患者骨髓来源CD34+白血病...
12 share 70% and 60% amino acid sequence identity in their p40 and p35 subunits, respectively. IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates ...
Blockade of interleukin-12 function by protein vaccination attenuates atherosclerosis [J]. Circulation,2005,112(7):1054-1062. [19] Zhang X,Niessner A,Nakajima T,et al. Interleukin 12 induces T-cell recruitment into the atherosclerotic plaque [J]. Circ Res,2006,98(4): 524-531. [20] Fang ...
and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine ...
https://www.cusabio.com/c-20630.html#:~:text=Interleukin%20is%20a%20kind%20of,a%20solid%20structure%20and%20function. https://mp.weixin.qq.com/s/_x83HGtWXqbW1tSZ-jULVQ Interleukins in cancer: from biology to therapy. Nat Rev Cancer. 2021 Jun 3 : 1–19. ...
Free p40 may act as an antagonist of IL-12 function. More recently, p35 was also found to dimerize with EBI3 (Epstein-Barr Virus-Induced Gene 3) to form IL-35. The biology of IL-35 is incompletely understood, and it is believed to be unique among the IL-12 family members in its ...
"16-7129 was used in Neutralization experiments to show that IRMs can modulate NK-cell function both in vitro and in vivo and that distinct indirect pathways control human NK-cell activation by TLR-7 and TLR-8 agonists." Authors Gorski KS,Waller EL,Bjornton-Severson J,Hanten JA,Riter CL,...
Pidasheva, S. et al. Functional studies on the IBD susceptibility geneIL23Rimplicate reduced receptor function in the protective genetic variant R381Q.PLoS ONE6, e25038 (2011). ArticleCASPubMedPubMed CentralGoogle Scholar Sarin, R., Wu, X. & Abraham, C. Inflammatory disease protective R381Q...