IL-11 reg- ulates macrophage effector function through the inhibition of nuclear factor- B. J. Immunol. 159:5661-5670.Trepicchio W, Wang L, Bozza M, Dorner A 1997 IL-11 regulates macrophage effector function through the inhibition of nuclear factor- B. J Immunol 159:5661-5670...
Interleukin-11 (IL-11) is a multifunctional cytokine essential in the differentiation and function of osteoclasts 24, 25 and IL-11 and its receptor are possible pathogenic factors in conditions associated with bone loss [26, 27]. IL-11 play important role in scoliosis patients The Members of ...
Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. FGF6 plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle...
Maternal IL-11Rα function is required for normal decidua and fetoplacental development inmice 来自 Semantic Scholar 喜欢 0 阅读量: 48 作者:P Bilinski,D Roopenian,A Gossler 摘要: In eutherian mammals, implantation and establishment of the chorioallantoic placenta are essential for embryo development...
In mouse models, IL11 overexpression causes fibrosis of the heart and kidney whilst genetic deletion of Il11ra1 protects against fibrosis and preserves organ function. Neutralizing antibodies against IL11 or IL11RA have been developed that have anti-fibrotic activity in human fibroblasts and protect ...
In human cancer patients, MDSCs are generally defined as monocytic (CD11b+, CD14+, HLA-DR−/low) or granu- locytic (CD11b+, CD15+) myeloid cells with antitumor immunosuppressive function. These populations have been observed in the blood of patients with glioblastoma, lung cancer, breast ...
Administration of anti-IL-11 to 75-week-old mice for 25 weeks improves metabolism and muscle function, and reduces ageing biomarkers and frailty across sexes. In lifespan studies, genetic deletion of Il11 extended the lives of mice of both sexes, by 24.9% on average. Treatment with anti-IL...
The regulation and function of the CD44 family of surface glycoproteins were investigated in human monocyte-derived dendritic cells (DCs). Variant CD44 iso... H Haegel-Kronenberger,HDL Salle,A Bohbot,... - 《Journal of Immunology》 被引量: 78发表: 1998年 Genome-wide association study identifie...
Function of IL1 1 4 1 . 1 .3 IL 1 1 signaling passway 5 1 . 1 .4 Biolog ical function of IL1 1 7 1 . 1 .4 . 1 IL1 1 in immunity 7 1 . 1 .4.2 IL 1 1 and tumorgenesis 8 1 . 1 .4.3 JAK -STAT3 signal passway and tumorigenesis ...
Administration of anti-IL-11 to 75-week-old mice for 25 weeks improves metabolism and muscle function, and reduces ageing biomarkers and frailty across sexes. In lifespan studies, genetic deletion ofextended the lives of mice of both sexes, by 24.9% on average. Treatment with anti-IL-11 ...