Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. FGF6 plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle...
Chronic inhibition of mTORC1 with rapamycin can cause glucose intolerance owing to indirect inhibition of mTORC235. It was therefore important to more fully assess the effects of IL-11 inhibition on liver function, metabolism and glucose utilization in old mice. As wild-type mice aged, there wer...
四、参考文献: A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome.PMID:35140116 Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis.PMID:31...
IL-11 Polyclonal Antibody for WB, ELISA Cat No.55169-1-AP Publications(9) Review Product Host / Isotype Rabbit / IgG Reactivity humanand More (2) Applications WB, IHC, ELISA Synonyms Adipogenesis inhibitory factor, AGIF, IL 11, IL11, IL-11, interleukin 11, Oprelvekin ...
Function of IL1 1 4 1 . 1 .3 IL 1 1 signaling passway 5 1 . 1 .4 Biolog ical function of IL1 1 7 1 . 1 .4 . 1 IL1 1 in immunity 7 1 . 1 .4.2 IL 1 1 and tumorgenesis 8 1 . 1 .4.3 JAK -STAT3 signal passway and tumorigenesis ...
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AbstractBackground: The function of eosinophils has been attributed to host defense, immunomodulation, and fibrosis. Although eosinophils are found among infiltrating cells in a broad spectrum of skin diseases, their pathogenic role remains uncertain. This study aimed to analyze the cytokine ...
The research team is now investigating whether IL-11 can stand in the way of the regeneration of other organs, like the kidneys, and whether it is involved in the loss of tissue function with advancing age. More information:Anissa A. Widjaja et al, Redefining IL11 as a regeneration-limiting...
Transmembrane p24 trafficking protein 3(TMED3) is a metastatic suppressor in colon cancer, but its function in the progression of hepatocellular carcinoma (HCC) is unknown. Here, we report that TMED3 was up-regulated in HCC and portal vein tumor thrombus. TMED3 up-regulation in HCC was ...