IL-2是一种多效细胞因子，在免疫系统中具有重要作用，具有免疫刺激或免疫抑制的“自相矛盾”的生物活性...
Alteration of interleukin 2 (IL-2) pharmacokinetics and function by IL-2 antibodies induced after treatment of colorectal carcinoma patients with a combination of monoclonal antibody 17-1A, granulocyte macrophage colony-stimulating factor, and IL-2. Clin Cancer Res. 2001 May;7(5):1163-70. PMID:...
[1] Chiossone, Laura et al. “Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells.” Blood vol.[2] 李焱,叶敬伟,郭晓玲.IL-12、IL-15对急性髓系白血病患者骨髓来源CD34+白血病细胞转化...
IL-2 promotes the function of memory-like autoregulatory CD8 + T cells but suppresses their development via FoxP3 + Treg cells (2013). IL-2 promotes the function of memory-like autoregulatory CD8+T cells but suppresses their development via FoxP3+ Treg cells . Eur. J. ... A Shameli,...
[23] Ross SH, et al. Signaling and function of interleukin-2 in T lymphocytes. Annual review of immunology. 2018 Apr 26;36(1):411-33. [24] Mitra S, et al. Biology of IL-2 and its therapeutic modulation: mechanisms and strategies. Journal of leukocyte biology. 2018 Apr;103(4):643...
More recently, the mechanisms by which IL-2 regulates CD4+ T cell differentiation and function have been elucidated. IL-2 also regulates the effector and memory responses of CD8+ T cells, and the loss of IL-2 or responsiveness to IL-2 at least in part explains the exhausted phenotype that...
3. Valencia, X., Yarboro, C., Illei, G. & Lipsky, P. E. Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol. 178, 2579-2588, (2007). 4. Comte, D....
IL-2 is indispensable for the development andfunction of regulatory T cells (Tregs) (12), whichare sensitive to IL-2 as a result of constitutiveexpression of CD25 and require IL-2Rb–dependentactivation of STAT5 signaling for survival andfunction (13) ...
Selection and expansion of natural killer cells for NK cell-based immunotherapy. Cancer Immunology, Immunotherapy 2016, 65(4):477-484. [3] Gaffen S, Liu K. Overview of interleukin-2 function, production and clinical applications. Cytokine 2004, 28(3):109-123....
2024年4月14日,来自瑞士洛桑大学Ludwig癌症研究所的Matteo Morotti等人在Nature上发表了题为“PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function”的文章。这篇论文研究了前列腺素 E2(PGE2)如何通过影响白细胞介素-2(IL-2)信号传导,抑制肿瘤浸润淋巴细胞(TIL)的扩增。研究发现,作...