Abul K. Abbas1, et al. Revisiting IL-2: Biology and therapeutic prospects. SCIENCE IMMUNOLOGY.Sa...
有意思的是IL-2其实是第一个被命名为白介素的细胞因子,因为当时科学界认为是有一个比IL-2功能层次更高的细胞因子刺激淋巴细胞产生IL-2,所以虽然是第一个被命名为白介素的细胞因子,却被命名为白介素-2号。(著名病毒学家,免疫学家:罗伯特·加洛,R...
Another pathway leads to c-myc gene induction by an as yet unknown mechanism. We discuss the complex signalling machinery that links the cell surface receptor to the nuclear events.doi:10.1146/annurev.iy.11.040193.001333Minami, YKono, TMiyazaki, TTaniguchi, TANNUAL REVIEW OF IMMUNO...
Interleukin 2 receptor regulation and IL-2 function in the human infant. Zola H,Ridings J,Elliott S,et al. Human Immunology . 1998Zola H,Ridings J,Elliott S,et al.Interleukin2receptor regulation and IL-2function in the human infant.Human Immunology. 1998...
[2] 李焱,叶敬伟,郭晓玲.IL-12、IL-15对急性髓系白血病患者骨髓来源CD34+白血病细胞转化为NK细胞作用研究[J].临床肿瘤学杂志,2019,24(01):32-37.[3] Perez, Sonia A et al. “Effect of IL-21 on NK cells derived from different umbilical cord blood populations.” International immunology vol. 18,...
More recently, the mechanisms by which IL-2 regulates CD4+ T cell differentiation and function have been elucidated. IL-2 also regulates the effector and memory responses of CD8+ T cells, and the loss of IL-2 or responsiveness to IL-2 at least in part explains the exhausted phenotype that...
Preferential expression of IL-2 receptor subunits on memory populations within CD4+ and CD8+ T cells. Immunology 72, 15–19 (1991). CAS PubMed PubMed Central Google Scholar Pekalski, M. L. et al. Postthymic expansion in human CD4 naive T cells defined by expression of functional high-...
[3]Perez, Sonia A et al. “Effect of IL-21 on NK cells derived from different umbilical cord blood populations.” International immunology vol. 18,1 (2006): 49-58. [4]Strengell, Mari et al. “IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and ...
(2013). IL-2 promotes the function of memory-like autoregulatory CD8+T cells but suppresses their development via FoxP3+ Treg cells . Eur. J. ... A Shameli,J Yamanouchi,S Tsai,... - 《European Journal of Immunology》 被引量: 24发表: 2013年 IL-2 promotes the function of memory-lik...
IL-2 is crucial for the production and function of Treg cells. We now show that IL-2 reduces IL-17(+) T cell differentiation in the tumor ... I Kryczek,S Wei,L Zou,... - 《Journal of Immunology》 被引量: 860发表: 2007年 Interleukin-2 is essential for CD4+CD25+ regulatory T ...