5. Abul K. Abbas1, et al. Revisiting IL-2: Biology and therapeutic prospects. SCIENCE IMMUNOLOGY.6. Sarah H. Ross and Doreen A. Cantrell, Signaling and Function of Interleukin-2 in T Lymphocytes. Annu. Rev. Immunol.
有意思的是IL-2其实是第一个被命名为白介素的细胞因子,因为当时科学界认为是有一个比IL-2功能层次更高的细胞因子刺激淋巴细胞产生IL-2,所以虽然是第一个被命名为白介素的细胞因子,却被命名为白介素-2号。(著名病毒学家,免疫学家:罗伯特·加洛,R...
Abul K. Abbas1, et al. Revisiting IL-2: Biology and therapeutic prospects. SCIENCE IMMUNOLOGY.Sa...
[2] 李焱,叶敬伟,郭晓玲.IL-12、IL-15对急性髓系白血病患者骨髓来源CD34+白血病细胞转化为NK细胞作用研究[J].临床肿瘤学杂志,2019,24(01):32-37.[3] Perez, Sonia A et al. “Effect of IL-21 on NK cells derived from different umbilical cord blood populations.” International immunology vol. 18,...
IL-12 can enhance the function of IL-2 by up-regulating CD25 in a p38 MAP kinase-dependent manner.doi:10.1002/(SICI)1521-4141(200005)30:5<1445::AID-IMMU1445>3.0.CO;2-Thang NguyenRuduan WangJohn H. RussellJohn Wiley & Sons, Ltd.European Journal of Immunology...
[2] T.R. Malek, The main function of IL-2 is to promote the development of T regulatory cells, Journal of leukocyte biology 74(6) (2003) 961-5. [3] S.A. Rosenberg, IL-2: the first effective immunotherapy for human cancer, Journal of immunology (Baltimore, Md. : 1950) 192(12)...
Kingston H. G.Mills. IL-17 and IL-17-producing cells in protection versus pathology. Nature Reviews Immunology, https://doi.org/10.1038/s41577-022-00746-9 Choong-Hyun Koh, et al. IL-17 and IL-21: Their Immunobiology and...
Human ImmunologyZola H, Ridings J, Elliott S, et al. Interleukin 2 receptor regulation and IL-2 function in the human infant[J]. Hum Immunol, 1998,59:615 - 620.Zola H, Ridings J, Elliott S, Nobbs S, Weedon H, Wheatland L, Haslam R, Roberton D and Macardle PJ: Interleukin-2 ...
1.本发明属于生物医药技术领域,具体的,涉及一种il-2与抗体亚单位构成的双功能融合蛋白。 背景技术: 2.白细胞介素2(il2)又称为t细胞生长因子,发现于1976年,在体外实验中刺激t细胞克隆扩增[1]。il2为四个α螺旋的糖蛋白,分子量为15.5kd[2],主要由活化的cd4 t细胞分泌,其它细胞如活化的cd8细胞、nk细胞、nkt细胞...
NCT02443155 A Clinical Proof-of-principle Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of NNC0114-0006 and Liraglutide on Preservation of Beta-cell Function。 不过只是轻微的改善疾病,可能原因是CD4+T产生更多的IL-21或者其他细胞因子的旁观者作用。