Alteration of interleukin 2 (IL-2) pharmacokinetics and function by IL-2 antibodies induced after treatment of colorectal carcinoma patients with a combination of monoclonal antibody 17-1A, granulocyte macrophage colony-stimulating factor, and IL-2. Clin Cancer Res. 2001 May;7(5):1163-70. PMID:...
1、肿瘤内PGE2通过调节IL-2的反应性抑制TIL的扩增。2、PGE2驱动TIL出现氧化应激并发生铁死亡。3、在TIL生产过程中阻断PGE2可以增强TIL-ACT的性能。 近日,瑞士洛桑大学的George Coukos教授团队在《Nature》杂志上发表了名为“PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function”的...
[1] Chiossone, Laura et al. “Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells.” Blood vol.[2] 李焱,叶敬伟,郭晓玲.IL-12、IL-15对急性髓系白血病患者骨髓来源CD34+白血病细胞转化...
More recently, the mechanisms by which IL-2 regulates CD4+ T cell differentiation and function have been elucidated. IL-2 also regulates the effector and memory responses of CD8+ T cells, and the loss of IL-2 or responsiveness to IL-2 at least in part explains the exhausted phenotype that...
Structure–function analysis of human interleukin-2. Identification of amino acid residues required for biological activity. J. Biol. Chem. 262, 5723–5731 (1987). Article CAS PubMed Google Scholar Sauvé, K. et al. Localization in human interleukin 2 of the binding site to the α chain (...
Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune responses. Their function and expression in the tumor microenvironment make them attractive targets for immunotherapy, leading to the development of IL-2/IL-2R-targeted t
梯形图（LD－Ladder Diagram） 功能块图（FBD － Function Block Diagram） 顺序功能图（SFC...
The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells. of Tr1 cells remain to be answered, but the development of therapeutic strategies designed to harness their immunoregulatory effects can already be ... MK Levings,R Bacchetta,U Schulz,... - ...
Εμφάνιση 2 ακόμα Frees anITEMIDLISTstructure allocated by the Shell. Syntax C++Αντιγραφή voidILFree( [in] PIDLIST_RELATIVE pidl ); Parameters [in] pidl Type:PIDLIST_RELATIVE A pointer to theITEMIDLISTstructure to be freed. This parameter can beNULL. ...
1:call int32 SomeFunction (string, int32, float64) 它的意思是函数SomeFunction返回一个int32(System.Int32)的类型, 传入其它三种类型string(System.String),int32(System.Int32) andfloat64(System.Double) 的参数. 注意这些都是CLR和IL汇编语言中的基本数据类型. 如果我们对非基本类型(自定义类型)是怎样处...