Analysis of CRC clinical samples showed that the high expression of IL-1β was closely related to the immunosuppressive function of tumor-infiltrated MDSCs. The results of in vitro experiments revealed that IL-1β was the most secreted cytokine of MDSCs stimulated by C. tropicalis. In vitro su...
C. tropicalispromotes excessive secretion of IL-1β from MDSCs via the NLRP3 inflammasome. IL-1β further enhances the immunosuppressive function of MDSCs to inhibit antitumor immunity, thus promoting the progression of CRC. Therefore, targeting IL-1β secreted by MDSCs may be a potential immuno...
Gain-of-function SNPs in NLRP3 and IL1B genes confer protection against obesity and T2D: undiscovered role of inflammasome genetics in metabolic homeostasis?No Abstract available for this article.doi:10.1007/s12020-017-1343-0de Moraes Rodrigues, Juliana...
Effect of Porphyromonas gingivalis and Lactobacillus acidophilus on Secretion of IL1B, IL6, and IL8 by Gingival Epithelial Cells Porphyromonas gingivalis alters cytokine expression in gingival epithelial cells, stimulating inflammatory responses that may lead to periodontal disease. ... Jun-jun,Zhao,Xi-...
functional alterations in VSMCs, including regulation of insulin-like growth factor (IGF) transport and uptake, IL-1B signaling pathway, and etc (Supplementary Fig.4c, d). Hence, we further explored the relative upregulation ofCDNK1Aand downregulation ofIGF1in the AC group indicated lowers ...
The levels of IL1B, IL6, and TNFA also significantly increased in the placentae of biopsied group. This study suggested that placental function may be sensitive to blastomere biopsy procedures, and placental oxidative stress and inflammation associated with blastomere biopsy may be critical factors ...
(n= 10); G and H: Hepatic mRNA level of tumor necrosis factor-alpha, interleukin 1β (Il1b), andIl6(G), andCcl2(H) (n= 10). Glyceraldehyde-3-phosphate dehydrogenase was used as an internal control for real-time quantitative polymerase chain reaction (C, D, G and H). ...
This suggests that there is subtle discordance in the regulation of the IFN response. Cluster 93 contains a small subset of the known Toll-like receptor (TLR)-inducible cytokines and chemokines including CXCL’s 1,2,3 and IL1B and IL8 (GO:0008009, chemokine activity, P < 5.4×10-10...
HMGB1, high-mobility group box 1 protein; IL, interleukin; LPS, lipopolysaccharide; RAGE, receptor for advanced glycation end-products; ROS, reactive oxygen species; TLR, Toll-like receptor. Cellular & Molecular Immunology Dual-function alarmins in the heart of inflammation and disease D Berthe...
Inflammatory diseases impair the reparative properties of endothelial progenitor cells (EPC); however, the involvement of diabetes in EPC dysfunction associated with myocardial infarction (MI) remains unknown. A model was established combining high-fat d