Cell migration is central to a multitude of physiological processes, including embryonic development, immune surveillance, and wound healing, and deregulated migration is key to cancer dissemination. Decades of investigations have uncovered many of the molecular and physical mechanisms underlying cell migrati...
International Journal of Biochemistry & Cell BiologyB. Wehrle-Haller, B.A. Imhof, Actin, microtubules and focal adhesion dynamics dur- ing cell migration, Int. J. Biochem. Cell Biol. 35 (1) (2003) 39-50.Wehrle2Haller , B. et al. Actin , microtubules and focal adhesion dynamics during ...
Mdm2 requires Sprouty4 to regulate focal adhesion formation and metastasis independent of p53 The molecular mechanism of how Mdm2 regulates cell migration remains to be elucidated. Here the authors report the role of Mdm2-x complexes, independent of p53, modulates the expression of Sprouty4 and regu...
m1600 focal adhesion kinase (fak) plays a critical role in early cell migration by affecting the microtubular cytoskeletondoi:10.1016/S0016-5085(09)61800-XLunn, J. AdrianRozengurt, EnriqueElsevier Inc.Gastroenterology
Retrograde fluxes of focal adhesion proteins in response to cell migration and mechanical signals. Mol. Biol. Cell 18, 4519–4527 (2007). Article CAS PubMed PubMed Central Google Scholar Galbraith, C. G., Yamada, K. M. & Galbraith, J. A. Polymerizing actin fibers position integrins ...
These data indicate that FliI regulates cell migration through its localization to focal adhesions and its ability to cap actin filaments, which collectively affect focal adhesion maturation.鈥擬ohammad, I., Arora, P. D., Naghibzadeh, Y., Wang, Y., Li, J., Mascarenhas, W., Janmey, P...
Recent studies suggest that integrin-mediated cell-matrix interaction can transduce biochemical signals across the plasma membrane to regulate cellular functions such as proliferation, differentiation and migration. These studies have implicated a critical role of focal adhesion kinase (FAK) in integrin-...
摘要原文 Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM), the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to direct mechanotransduction, cell migration, cell cycle progression, proliferation, differentiation, grow...
migrationvitronectinp125 focal adhesion kinase (p125FAK) is a cytoplasmic tyrosine kinase that is activated upon engagement of integrin cell adhesion receptors, and initiates several signaling events that modulate cell function in vitro. To determine the biologic role of p125FAK in malignant astrocytic...
The aim of the present study was to analyze the expression of focal adhesion kinase (FAK) in osteosarcoma (OS) cell lines with different migration abilities in order to determine the role of FAK in migration. A number of different 143B subclone cell lines (A1, A2, A3, A4 and A5) were...