Ion elemental-optimized layered double hydroxide nanoparticles promote chondrogenic differentiation and intervertebral disc regeneration of mesenchymal stem cells through focal adhesion signaling pathway. Bioactive Materials, 22, (2023) ...
Focal adhesion kinase signaling pathways regulate the osteogenic differentia- tion of human mesenchymal stem cells. Exp Cell Res. 2007;313:22-37.Salasznyk RM, Klees RF, Williams WA, Boskey A, Plopper GE (2007) Focal adhesion kinase signaling pathways regulate the osteogenic differentiation of ...
High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype Focal adhesion kinase (FAK) is a protein tyrosine kinase expressed in invasive breast cancer that regulates antiapoptotic signaling. We have examined FAK e... AL Lark,CA Livasy,L Dressler,...
摘要: Choroidal neovascularization (CNV) is one of the most frequent causes of severe and progressive vision loss, while its pathogenesis is still poorly understood. Focal adhesion kinas... 查看全部>>关键词: focal adhesion kinase choroidal neovascularization retinal pigment epithelial cells hypoxia ...
生川乌 ; 毒性 ; 信号通路 ; Focal adhesion [摘要] 目的寻找生川乌的毒性基因,探讨其毒性机制。方法根据国际ICH的要求,在SPF实验条件下采用生川乌水煎液ig昆明种小鼠进行毒性实验。采用基因表达谱技术,就生川乌对小鼠5种脏器的毒性进行全基因组描绘,应用Cluster、GO和Pathway等生物信息学手段对获取的数据进行综合分...
Local Signaling in Myocytes K.G.Franchini, inJournal of Molecular and Cellular Cardiology, 2012 1Introduction Focal adhesion kinaseis a 125kDa non-receptor proteintyrosinekinase discovered as a substrate for v-Src in transformed fibroblasts[1–3]. Concurrent with this initial observation came the rec...
Various neutrophil functions such as phagocytosis, superoxide production, and survival are regulated by integrin signaling. Despite the essential role of focal adhesion kinase (FAK) in mediating this signaling pathway, its exact function in neutrophils is ill defined. In this study, we investigated the...
Focal adhesion kinase (FAK) mediates myriad cellular functions and has been found to be over-expressed in numerous human cancers. We recently explored the role of FAK in promoting the aggressive phenotype of melanoma cells, characterized by increased invasion, migration, and vasculogenic mimicry (VM...
PD98059, a MEK inhibitor, also inhibited IL-1α-induced enhancement of adhesion and invasion in pancreatic cancer cells.Our results demonstrated that activation of FAK is involved with the aggressive capability in pancreatic cancer through Ras/ERK signaling pathway. Based on our results, we suggest...
We further show that a functional effect of Flii at both the cellular level and in in vivo mouse wounds is through inhibiting paxillin tyrosine phosphorylation and suppression of signaling proteins Src and p130Cas, both of which regulate adhesion signaling pathways. Flii is upregulated in response...