Cellular biology A novel signaling pathway that governs cell adhesion RENSSELAER POLYTECHNIC INSTITUTE Andrea Page-McCaw ZhangShuningMMPs (Matrix Metalloproteinases) are a family of extracellular proteases. They can mediate tissue remodeling. Their main function is to cleave substrates including extracellular...
Fig. 2: Validation of the adhesion screen by targeted inhibition of BCR-controlled integrin-mediated adhesion. a The BCR signaling pathway. Proteins represented by guides in the Brunello library are shown in black. The guides corresponding to the kinase(-related) genes encoding proteins in yellow ...
(视觉偏好基因的适应性渗入) 8. Determination of single-molecule loading rate during mechanotransduction in cell adhesion (在细胞粘附过程中力学转导单分子加载速率的测定) Cell Weekly 滑动阅览 1. A gut-derived hormone regulates choleste...
Cell adhesion has tremendous impact on the function of culture platforms and implants. Cell-adhesive proteins and peptides have been extensively used for decades to promote cell adhesion, however, their application suffers from their easy enzymatic degra
initiating factor(s) for transcriptional activation of adhesion molecules via the NF-κB signaling pathway, because genes for adhesion molecules including vascular cell adhesion molecule-1 are conserved downstream of the transcriptional region activated by NF-κB. Other literature shows that oxHDL ...
ocal adhesion kinase; GAP, GTPase-activating protein; GEF, guanine nucleotide exchange actor; GSK3β, glycogen synthase kinase 3-beta; hScrib, human homolog o scribble; JAM, junctional adhesion molecule; JRAB, junctional Rab13-binding protein; LEF/TCF, lymphoid enhancer actor-1/T cell actor-1...
domain. It is present in some mammals, including rats, mice, chimpanzees, and humans [9,104], but not in others, such as dogs [105]. Nevertheless, the phosphorylation of Y852 has been shown to play a critical role in the activation of Src-focal adhesion kinase (FAK) signaling [164]....
adhesion.β-catenin is also the key player in theWnt signaling pathway, a pathway important in regulation of bone mass (Westendorfet al.,2004). Current work is trying to unravel interconnections between Wnt signaling and cadherin-mediated cell adhesion through regulation of freeβ-catenin levels ...
巨核细胞和中性粒细胞形成emperipolesis的过程由β-整合素、细胞间黏附分子1 (intercellular adhesion molecule-1, ICAM-1)和ezrin介导的黏附开始,随后中性粒细胞进入巨核细胞的细胞质并驻留在囊泡中。囊泡的膜被溶解,将中性粒细胞释放到宿主的细胞质...
potential to dephosphorylate proteins belonging to signaling pathways involved in the regulation of adhesion [1,2,4]. In cancer cells, this may lead to dephosphorylation of proteins important in oncogenic signaling. Recently, PTPRF/LAR has been shown to have both the tumor suppressive and oncogenic...