原本我设想了一个爬虫思路:首先,定位到Cell Signaling官网的通路图页面,然后利用爬虫技术提取每一个通路图对应的PDF链接,最后通过自动化脚本批量下载这些PDF文件。 然而,在我深入探索之后,惊喜地发现,Cell Signaling官网已经为我们提供了非常便捷的下载方式。在这个链接中,我们可以直接下载到所有的通路图PDF文件,无需任何...
I.Signalingmolecules: Diversity,Receptors,GTPaseswitchproteins,proteinkinases, adaptorproteins,proteinphosphatases II.SignalingPathways: A.Cell-surfacereceptorpathways(receptorsthatareIonchannels, SignalingthroughG-protein-coupledreceptors,Signalingthrough Enzyme-linkedreceptors,Signalingthatinvolvedinproteolysis) B.Intrace...
TightandAdherensJunctionSignalingJenniferL.HarderandBenMargolisDepartmentsofInternalMedicineandBiologicalChemistry,UniversityofMichigan,AnnArbor,MI48109,USASignalingpathwaysconverginguponandemanating romadherensjunctions(AJs)andtightjunctions(TJs)a ectmanycellular unctions,includingcytoskeletaldynamics,polarizedvesicletra f...
Cell Signaling Technology(CST)是一个专业抗体公司,在网站提供了很多专业的信号转导通路信息,是科研入门必备。分享CST对AD的信号转导图,需要学习的可以在官方网站获取高清图片/PDF文件。 来源网页链接 阿尔茨海默病是全球最常见的神经退行性疾病之一。临床上,其特征为存在胞外淀粉样斑块以及胞内神经原纤维缠结,进而导...
cargodestined orrecycling(requiringRab11andpossiblyRab4)or orlateendosome/lysosomaldegradation(requiringRab7)canoccuratthelevelo clathrin-coatedpitsandbecom-pletedinearlyendosomalsubdomains.Transporto cargo romearlyendosomestothetrans-Golginetworkrequirestheretromerproteincomplex.Pathwayso EndocytosisEndocyticpathwaysca...
C. Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling. Mol. Cancer Ther. 13, 855–866 (2014). Article CAS PubMed PubMed Central Google Scholar Li, X., Wu, J. B., Chung, L. W. & Huang, W. C...
Signaling pathways involved in the cell cycle regulation and DNA repair, epigenetic regulation, cell metabolism, tumor immunity and angiogenesis are recognized as targetable candidates [17], yet the corresponding clinical trials have progressed slowly with most failing to provide promising results. Notch ...
ToolsforysisofT-cellSignaling Tcellsareactivatedandregulatedbycomplexpathways IL-6 involvinganumberofsignaltransductionmolecules, Cytosmludingreceptorsforandcytokines,kinases,and GP130IL-6Rtranscriptionfactors.Whenforeignenterthebody, SHCtheyarerecognizedbytheinnateimmunesystem,whichin turnrespondswiththeexpressionof...
The cytoskeleton as regulator of cell signaling pathways Trends Biochem Sci, 45 (2020), pp. 96-107 View PDFView articleView in ScopusGoogle Scholar This important paper proposes that the cytoskeleton can control the spatiotemporal output and the intensity of signaling events, and provides examples....
S100A8 and S100A9 activate MAP kinase and NF-kappaB signaling pathways and trigger translocation of RAGE in human prostate cancer cells. Exp. Cell Res. 312, 184–197 (2006). Article CAS PubMed Google Scholar Ghavami, S. et al. S100A8/A9 induces autophagy and apoptosis via ROS-mediated...