Cell adhesion molecules (CAMs) are glycoproteins uniformly present on the cell surface. They are responsible for cell-to-cell and cell-to-extracellular environment interactions such as adhesion, growth, migration. They are expressed on the surface of the immune cells and take part in various ...
Cell adhesion molecules structure and function in normal tissues Role of adhesion molecules in migration Loss of cell adhesion during malignant transformation Cell adhesion in invasiveness by collective migration Cell-cell interactions and collective migration in three-dimensional cultures Integrins, three-dime...
Cell adhesionmolecules (CAMs) have been implicated inendothelial injuryand leukocyte-endothelial interactions underlying both arthritis andatherosclerosis[10,74]. Among CAMs, numerous β1 and β2integrins, intercellular (ICAM-1 and ICAM-3), platelet-endothelial (PECAM-1) and vascularcell adhesion molecu...
we performed RT-PCR assays using PCR Array (Human Extracellular Matrix and Adhesion Molecules RT2 ProfilerTM PCR Array, 84 genes total) on (i) hESC-ECs suspension in PBS, (ii) hESC-ECs suspension in Matrigel and (iii) cultured hESC-ECs as positive controls (n = 4/group). We...
We have examined the distribution of several cell adhesion molecules (CAMs) in the developing chick olfactory system and brain to determine whether differential distributions of these adhesion molecules might be important in pathway choices made by migrating LHRH neurons. Single- and double-label ...
Cell adhesion molecules (CAMs) are now known to mediate much more than adhesion between cells and between cells and the extracellular matrix. Work by many researchers has illuminated their roles in modulating activation of molecules such as receptor tyrosine kinases, with subsequent effects on cell ...
The most direct effects may be contributed by synaptic adhesion molecules, which are known to be involved in synaptic plasticity of sensory neurons. We have mapped heritability to two specific types of primary sensory neurons. However, as previously mentioned, we do not explain the full ...
Neurons contact their neighbors through a diverse array of cell adhesion and other surface molecules. These molecules can exhibit highly regulated patterns of expression, underscoring their multiple roles in establishing specific interactions between neurons and their environment. Recent studies are beginning...
important roles not only in cell adhesion but also in cellular signaling, cell migration, proliferation and differentiation[165,166]. EpCAM shows tumor initiation, proliferation, invasion, metastasis[167]and chemo-/radio sensitivity through PI3K/Akt/mTOR signaling pathway activation inprost...
NCAMs are a family of cell surface glycoproteins that accomplish Ca2+-independent adhesion, either through homophilic or heterophilic binding, between molecules on neighboring cells or between cell and ECM proteins. From: Functional Neurobiology of Aging, 2001 ...