Formation and disassembly of FAs are regulated dynamically during cell migration. Adhesion to the ECM has been studied mainly using cells cultured on an ECM-coated substratum, where the rate of cell migration is determined by the turnover of FAs. However, the molecular events underlying the ...
Together with protrusion extension and cell body retraction, adhesion to the substrate via specific focal adhesion points has long been considered an essential step in cell migration. Although this is true for cells moving on two-dimensional substrates, recent studies have demonstrated that focal ...
Sheets, K., Wunsch, S., Ng, C. & Nain, A. S. Shape-dependent cell migration and focal adhesion organization on suspended and aligned nanofiber scaffolds. Acta Biomater 9, 7169-7177 (2013).Sheets, K., Wunsch, S., Ng, C., and Nain, A. S., 2013, "Shape-dependent cell migration ...
BMC Cell BiologyCastelli, M.; de Pascalis, C.; Distefano, G.; Ducano, N.; Oldani, A.; Lanzetti, L.; Boletta, A. Regulation of the microtubular cytoskeleton by polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration. BMC Cell Biol. 2015, 16, 15, doi:...
www.nature.com/scientificreports OPEN Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal received: 28 August 2015 accepted: 19 November 2015 Published: 18 December 2015 adhesions to regulate cell adhesion and migration Jui-Chung Wu1,Yu-Chen Chen1,...
25 In this study, the effects of LMP1 were largely assessed in the spontaneously immortalized non-tumorigenic, non-metastatic breast epithelial cell line MCF10a. In these cells, LMP1 induced features of EMT and increased adhesion and transwell migration to fibronectin. Inhibition of integrin-α5 or...
cell-to-extracellular matrix adhesion, FAK is implicated in the regulation of manybiological processes, with particular emphasis oncell proliferation, migration and survival[6,7]. The involvement of FAK in this range of functions supports its role in important aspects of organismal development and ...
Focal adhesion (FA) proteins assemble into intracellular complexes involved in integrin-mediated communication between the extracellular matrix and the actin cytoskeleton, regulating many cell physiological processes including the cell cycle. Interestingly, recent studies report that integrins bind to Aβ ...
Integrins, Cell Matrix Interactions and Cell Migration Strategies: Fundamental Differences in Leukocytes and Tumor Cells The principles determining the migration of different cell types may result from their differences in origin, size and shape, function of adhesion receptor... P Friedl,EBB And,KS Z...
One event regulated by the physical structure of the ECM is phosphorylation of focal adhesion kinase (FAK) at Y397, which couples FAK to several signaling pathways that regulate cell proliferation, survival, migration, and invasion. 展开 关键词:...