and heme-induced ferroptosis was accompanied by significant changes in the mRNA and protein expression of molecules related to the Notch signaling pathway.183Notably, DFO cotreatment effectively rescued heme-induced ferroptosis and inhibition of Notch pathway activation,183suggesting that heme-induced cell ...
Using Kyoto Encyclopedia of Genes and Gnomes (KEGG) pathway enrichment analysis, Yang et al. found that dexamethasone treatment induced activation of the ferroptosis pathway. EC-Exos could resist glucocorticoid-induced inhibition of osteoblasts by inhibiting ferrophagy-dependent ferroptosis in vitro and ...
and heme-induced ferroptosis was accompanied by significant changes in the mRNA and protein expression of molecules related to the Notch signaling pathway.183Notably, DFO cotreatment effectively rescued heme-induced ferroptosis and inhibition of Notch pathway activation,183suggesting that heme-induced cell ...
C. The first 20 entries of the KEGG pathway enrichment analysis of DEGs. Notably, the p53 signaling pathway was significantly affected (red box). D. Molecular docking of baicalin and the P53 protein. E, F, G. HL-7702CYP3A4 cells were pretreated with 1 µmol/L AFB1 for 24 h and...
During these processes, chemical鈥損rotein interaction (CPI), protein鈥損rotein interaction (PPI), the Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted. Multivariate logistic regression analysis was used to test...
KEGG pathway mapping revealed downregulation of genes associated with Janus-associated kinase (JAK)- Signal transducers and activators of transcription (STAT) signaling in Epha2–/– BMDCs, while genes of the peroxisome proliferator-activated receptors (PPAR) pathway were upregulated (Fig. 5d). To ...
We used GO and KEGG enrichment analysis to discover the following three mRNA candidates enriched in the axonal growth cone pathway: RTN4R, GPM6A, Smo. We predicted that Smo has a binding site for miR-6315 by using the Ensembl database and Miranda software. The miR-6315/Smo ax...
Using Kyoto Encyclopedia of Genes and Gnomes (KEGG) pathway enrichment analysis, Yang et al. found that dexamethasone treatment induced activation of the ferroptosis pathway. EC-Exos could resist glucocorticoid-induced inhibition of osteoblasts by inhibiting ferrophagy-dependent ferroptosis in vitro and ...
Notably, KEGG pathway analysis further revealed two key pathways dramatically affected by HG-induced HK-2 cells, including ferroptosis and cytokine-cytokine receptor interaction (Fig. 2E), which have also been reported to be associated with ferroptosis. Collectively, RNA sequencing confirmed abnormal ...
GO and KEGG pathway enrichment of five ferroptosis-related genes. a GO analysis. BP biological process, CC cellular component, MF molecular function. b KEGG pathway enrichment analysis. Count indicates the level of enrichment. Different colors represent the p-value Full size image Construction of ce...