During these processes, chemical鈥損rotein interaction (CPI), protein鈥損rotein interaction (PPI), the Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted. Multivariate logistic regression analysis was used to test the associated pathway....
Kyoto Encyclopedia of Gene and Genomes (KEGG) pathway enrichment analysis was conducted using an online platform (http://www.bioinformatics.com.cn/) that analyzes and visualizes data [20]. Construction of ceRNA networks We predicted interactions between ferroptosis-related mRNAs and miRNAs by using ...
Using Kyoto Encyclopedia of Genes and Gnomes (KEGG) pathway enrichment analysis, Yang et al. found that dexamethasone treatment induced activation of the ferroptosis pathway. EC-Exos could resist glucocorticoid-induced inhibition of osteoblasts by inhibiting ferrophagy-dependent ferroptosis in vitro and ...
we also found that P53 signaling pathway geneset from Kyoto Encyclopedia of Genes and Genomes (KEGG) database was significantly enriched in the group with low STAT6 expression by GSEA (Fig.4D). These findings suggest that STAT6 attenuates ferroptosis in lung injury by negatively regulating P53 s...
Using Kyoto Encyclopedia of Genes and Gnomes (KEGG) pathway enrichment analysis, Yang et al. found that dexamethasone treatment induced activation of the ferroptosis pathway. EC-Exos could resist glucocorticoid-induced inhibition of osteoblasts by inhibiting ferrophagy-dependent ferroptosis in vitro and ...
We used the Database for Annotation, Visualization, and Integrated Discovery (DAVID) Bioinformatics Resources 6.8 to analyze functional and pathway enrichments through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotations (Wang et al., 2022). Bar charts were plo...
a Up- and down-regulated number of genes of KEGG pathways. RNASeq was performed on mRNA isolated from kidneys of WT and Epha2−/− mice after 3 days of infection. N = 3 per mouse strain. b GSEA of ferroptosis pathway genes. Heatmap of ferroptosis gene expression analysis in WT...
gene, has lost the ability to induce cell cycle arrest, senescence and apoptosis, but it can enhance the susceptibility of cells to ferroptosis [47,84]. The P53 3KR knockin mice will not form spontaneous tumors, which proves the existence of ferroptosis-induced anti-tumor pathway of p53 [47...
Notably, KEGG pathway analysis further revealed two key pathways dramatically affected by HG-induced HK-2 cells, including ferroptosis and cytokine-cytokine receptor interaction (Fig. 2E), which have also been reported to be associated with ferroptosis. Collectively, RNA sequencing confirmed abnormal ...
We analyzed the GO system involved in DE mRNAs and the KEGG pathway with a critical effect on SCI to further enrich the axonal growth cone pathway, including the gene sets RTN4R, GPM6A, and Smo (Figure 3A). We used the Ensembl database to screen three target gene sequences...