Within the last decade, fatty acid metabolism has become a focus of cancer biology and translational research. Fatty acid synthesis, a pathway found in liver and adipose tissue, which transforms excess dietary carbohydrate calories to fatty acids for energy storage, has been found to be expressed ...
Recent research has also shown that multiple lipid metabolic pathways are altered in cancer cells. Here, we provide a brief review for the role of fatty acid metabolism in cancer development with a special focus on fatty acid uptake and de novo synthesis, triglycerides synthesis, storage and ...
A common feature of cancer cells is their ability to rewire their metabolism to sustain the production of ATP and macromolecules needed for cell growth, division and survival. In particular, the importance of altered fatty acid metabolism in cancer has received renewed interest as, aside their prin...
However, our current knowledge about fatty acid metabolism in cancer cells remains limited, and the investigations of such processes and related pathways are certainly warranted to reveal the clinical relevance of fatty acid metabolism in cancer diagnosis and therapy. 展开 关键词: Cancer metabolism ...
Fatty acid metabolism in the TME of ovarian cancer (Yoon et al., 2022). Detection of Fatty Acid Metabolism The detection and quantification of fatty acid metabolism rely heavily on mass spectrometry (MS). It has a high sensitivity, specificity, and can evaluate a wide variety of fatty acid ...
acid metabolism, fatty acid metabolism supports tumorigenesis and disease progression through a range of processes including membrane biosynthesis, energy storage and production, and generation of signaling intermediates. Here, we highlight the complexity of cellular fatty acid metabolism in cancer, the ...
"Dietary consumption of omega-3 fatty acids can lead to the formation of these substances in the body and may have some beneficial effects," said study leader Aditi Das, a professor of comparative biosciences and an affiliate of biochemistry at UI. "If you have cancer, you want something con...
Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells. Curr. Opin. Clin. Nutr. Metab. Care 9, 346–357 (2006). Article CAS PubMed Google Scholar Kuhajda, F. P. Fatty acid synthase and cancer: new application of an old ...
Here, we highlight the complexity of cellular fatty acid metabolism in cancer, the various inputs and outputs of the intracellular free fatty acid pool, and the numerous ways that these pathways influence disease behavior.Background Cancer cells have distinctive metabolic phenotypes compared to normal...
Fatty acid metabolismcan contribute to important needs ofcancer cells: energy, growth, and membrane synthesis. Furthermore, fatty acids are catabolized byfatty acid oxidation, which is an important source ofnicotinamide adenine dinucleotide phosphate(NADPH). Cancer cells require NADPH, which is used ...