Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer. Cell Death Dis. 7, e2226.Qu Q, Zeng F, Liu X, Wang QJ and Deng F. Fatty acid oxidation and carnitine palmitoyltransfer- ase I: emerging therapeutic targets in cancer. Cell Death Dis 2016; 7:...
The National Cancer Center (NCC) said on Tuesday that its anti-cancer drug targeting fatty acid oxidation inhibition, KN510713, was approved to enter clinical trials by the Ministry of Food and Drug Safety (MFDS) on Wednesday. The National Cancer Center (NCC) said on Tuesday that its anti-c...
Recent research has pointed to the crucial role of fatty acid oxidation (FAO) as an essential source of NADH, FADH2, NADPH and ATP, all providing survival advantage to cancer.5, 6, 7 As the key rate-limiting enzyme of FAO, carnitine palmitoyltransferase I (CPTI) controls FAO directly and ...
Tamoxifen-based endocrine therapy remains a major adjuvant therapy for estrogen receptor (ER)-positive breast cancer (BC). However, many patients develop tamoxifen resistance, which results in recurrence and poor prognosis. Herein, we show that fatty acid oxidation (FAO) was activated in tamoxifen-...
Fatty acid oxidation is required for de novo synthesis of nucleotides in endothelial cell, thus functional angiogenesis. • The importance of other aspects of endothelial fatty acid metabolism requires further detailed investigation. • Cancer fatty acid metabolism is required for survival and growth ...
Fatty Acid oxidation mediated by acyl-coa synthetase long chain 3 is required for mutant kras lung tumorigenesis. Cell Rep 2016; 16: 1614-1628.Padanad, M.S.; Konstantinidou, G.; Venkateswaran, N.; Melegari, M.; Rindhe, S.; Mitsche, M.; Yang, C.; Batten, K.; Huffman, K.E.;...
Here, we highlight the complexity of cellular fatty acid metabolism in cancer, the various inputs and outputs of the intracellular free fatty acid pool, and the numerous ways that these pathways influence disease behavior.Background Cancer cells have distinctive metabolic phenotypes compared to normal...
Cancer metabolism: fatty acid oxidation in the limelight. Warburg suggested that the alterations in metabolism that he observed in cancer cells were due to the malfunction of mitochondria. In the past decade, we h... A Carracedo,LC Cantley,PP Pandolfi - 《Nature Reviews Cancer》 被引量: 526...
Evidence for the anticarcinogenic activity of the conjugated dienoic derivatives of linoleic acid (CLA) is reviewed. CLA is present in grilled beef, cheese, and related foods. It is also generated endogenously via carbon centered free radical oxidation of linoleic acid. New findings indicate that ...
Cancer cells need to adapt their metabolic state to different microenvironments, particularly during metastatic spread, when they are exposed to the circulatory system as well as the distant organ. Two studies now show that upregulation of fatty acid syn