Altered lipid metabolism is a characteristic feature of cancer cells. This systematic review assesses the risk for cancer development in association with the expression levels of the ACACA and ACACB genes which encode the rate limiting enzymes of fatty acid synthesis, acetyl-CoA carboxylase 伪 (ACC...
Our studies reveal that fatty-acid- and ZDHHC19-mediated palmitoylation are signals that regulate STAT3, which provides evidence linking the deregulation of palmitoylation to inflammation and cancer. This is a preview of subscription content, access via your institution Access options Access Nature and...
Such an original approach would involve two successive phases of breast cancer treatment: an initial sensitization of residual tumor cells to chemotherapy and to radiation therapy with dietary DHA; then a prevention of metastatic re-growth with a prolonged rumenic acid supplementation. Safety is not ...
OBJECTIVE: Dietary fat, including specific fatty acids, has been proposed to contribute to prostate cancer pathogenesis, but findings from the studies based on biomarkers have been conflicting. METHODS: We examined the association between erythrocyte membrane fatty acid composition and prostate cancer risk...
Kuhajda, F. P. Fatty-acid Synthase and human cancer: new perspectives on its role in tumor biology.Nutrition16, 202–208 (2000).First review documenting the relationship between FASN-catalysed endogenous FA biogenesis and tumour biology.
Int J Cancer 124:924-931... ACM Thiébaut,V Chajès,M Gerber,... - 《International Journal of Cancer》 被引量: 254发表: 2010年 Dietary conjugated linoleic acid and long-chain n-3 fatty acids in mammary and prostate cancer protection: a review The role of dietary fatty acids on cancer ...
Research showed no correlation between BMI and fatty acid fractions in breast tissue, suggesting that the type of fat that makes up fattybreast tissuegives new information beyond the amount of overall body fat. "Our research is ongoing," Dr. Kim said. "We need to investigate these higher leve...
Researchers have demonstrated that a fatty acid called dihomogamma-linolenic acid, or DGLA, can kill human cancer cells. The study, published inDevelopmental Cellon July 10, found that DGLA can induce ferroptosis in an animal model and in actual humancancercells. Ferroptosis is an iron-dependent...
Fatty acids are fundamental substrates required for energy storage, synthesis of membranes, generation of signaling molecules and lipid droplet formation in cancer cells. High levels of fatty acid metabolic activity are one of the most aberrant metabolic alterations in cancer cells. The de novo fatty...
Conjugated linoleic acid (CLA) is a naturally occurring group of dienoic derivatives of linoleic acid found in the fat of beef and other ruminants. CLA is ... Y Ha - 《Cancer Research》 被引量: 933发表: 1990年 Formation and Action of Anticarcinogenic Fatty Acids Conjugated dienoic derivatives...