Our studies reveal that fatty-acid- and ZDHHC19-mediated palmitoylation are signals that regulate STAT3, which provides evidence linking the deregulation of palmitoylation to inflammation and cancer. This is a preview of subscription content, access via your institution Access options Access Nature and...
comprising dietary omega-3 fatty acid supplementation and, in populations consuming a high fat diet a reduction in total fat and omega-6 fatty acid intake, may have a place not only in breast cancer prevention, but also as an adjunct to the surgical treatment of the breast cancer patient. ...
Fatty Acids That Inhibit Cancer: Conjugated Dienoic Derivatives of Linoleic Acid Abstract Evidence for the anticarcinogenic activity of the conjugated dienoic derivatives of linoleic acid (CLA) is reviewed. CLA is present in grilled beef, cheese, and related foods. It is also generated endogenously v...
OBJECTIVE: Dietary fat, including specific fatty acids, has been proposed to contribute to prostate cancer pathogenesis, but findings from the studies based on biomarkers have been conflicting. METHODS: We examined the association between erythrocyte membrane fatty acid composition and prostate cancer risk...
Researchers have demonstrated that a fatty acid called dihomogamma-linolenic acid, or DGLA, can kill human cancer cells. The study, published inDevelopmental Cellon July 10, found that DGLA can induce ferroptosis in an animal model and in actual humancancercells. Ferroptosis is an iron-dependent...
Kuhajda, F. P. Fatty-acid Synthase and human cancer: new perspectives on its role in tumor biology.Nutrition16, 202–208 (2000).First review documenting the relationship between FASN-catalysed endogenous FA biogenesis and tumour biology.
sterically incompatible relationship between docosahexaenoic acid, sphingolipids, and cholesterol, the major constituents of lipid rafts, n-3 PUFA modulate these crucial membrane microdomains and perturb efficient signal transduction thereby eliciting the same biological effects exploited by some anti-cancer ...
High-fat diets may increase the risk of cancer at sites such as the breast, colon, pancreas and prostate, although the evidence is somewhat mixed. The type of fat can affect its influence on cancer in experimental animals, but in humans on diets of mixed foodstuffs the quantity rather than...
A similar positive association was found between intake of elaidic acid, the predominant ITFA, and breast cancer risk (HR for highest vs lowest quintile, 1.14, 95% CI 1.06–1.23; P trend = 0.001). Intake of total RTFAs was also associated with higher breast cancer risk (HR for ...
at the University of Chicago Biological Sciences Division found that trans-vaccenic acid (TVA) – a long-chain fatty acid in meat and dairy products from grazing animals like cows and sheep – improves the ability of CD8+ T cells in the immune system infiltrate tumors and kill cancer cells....