Molecular CancerGelsomino G, Corsetto PA, Campia I, Montorfano G, Kopecka J, Castella B, Gazzano E, Ghigo D, Rizzo AM, Riganti C. Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes ...
in Teflon-lined screw-capped tubes and resuspended in 1mL 15% NaOH in methanol/water (1:1, v/v). Forcell lysisandsaponificationof fatty acids this suspension is incubated at 100°C for 30min. For the followingmethylationof fatty acids, 2mL 6.0N HCl/methanol (1.2:1, v/v) are added ...
Blocking FAO and/or leptin re-sensitizes them to chemotherapy and inhibits BCSCs in mouse breast tumors invivo . We identify a critical pathway for BCSC maintenance and breast cancer chemoresistance. 展开 关键词: JAK/STAT3 breast cancer stem cell chemoresistance fatty acid β-oxidation leptin ...
In the tumor environment, hypoxia promotes tumor progression, such as cancer cell growth, migration and chemoresistance. This study aimed to evaluate the roles of free fatty acid receptors (FFARs) in the regulation of cancer cell functions under hypoxic conditions, using fibrosarcoma HT1080 cells. ...
The importance of fatty acid (FA) metabolism in cancer is well-established, yet the mechanisms underlying metabolic reprogramming remain elusive. Here, we identify tetraspanin CD37, a prognostic marker for aggressive B-cell lymphoma, as essential membran
35 These studies suggested that FAO inhibition is a potential strategy to overcome drug resistance in tumors. Besides chemoresistance, the ability to survive in hypoxia is also significant for tumor cells. How do FAO work under hypoxia in cancer cells? In tumor tissue, intermittent blood supply ...
The role of immune cells in the tumor microenvironment (TME) and their association with abnormal fatty acids metabolism in ccRCC remains poorly understood. Method RNA-seq and clinical data of KIRC from The Cancer Genome Atlas (TCGA) and E-MTAB-1980 from the ArrayExpress dataset. The Nivolumab ...
However, lipids can influence cancer cell biology via a range of mechanisms, which include but are not limited to, fatty acids as substrates for mitochondrial ATP synthesis [22], arachidonic acid (20:4(ω-6)) as the pre-cursor for eicosanoid synthesis (see review [23]), post-translational...
However, the role of fatty acids in the regulation of HIF-1 activity and cancer cell survival has not been investigated. In this study, we analyzed the relationship between changes in lipid metabolism and HIF-1α-interacting proteins using proteomics and identified fatty-acid-binding protein 5 (...
Larry Fliegel, in Prostate Cancer Metabolism, 2021 Fatty acid synthase This is a multienzymatic complex that works as a dimer and synthesizes fatty acids. The growing fatty acids move from one enzyme of the complex to the other, and the successive steps of two-carbon elongation are carried ...