Key secondary endpoints were (a) association between 68Ga-FAPI-46 uptake intensity and histopathologic FAP expression, (b) accuracy of 68Ga-FAPI-46 versus 18F-FDG PET, (c) impact on management, (d) inter-reader reproducibility, (e) safety, and (f) change in staging/prognostic groups. ...
作者将MSC又细分为10种亚群: Telocytes were positive for SOX6, FOXL1, and F3 expression9, which were further sub-clustered based on ICAM1 expression into ICAM1+ telocytes (n = 1016) and ICAM1− telocytes (n = 550) Myofibroblasts were clustered based on the high expression of ...
Fibroblast activation protein (FAP) is not only specifically expressed in cancer-associated fibroblasts (CAFs) of most neoplastic diseases, but also highly expressed in some diseases characterized by tissue remodeling. FAP inhibitors (FAPIs) PET can target the distribution of FAP in tissues and organs...
4. Chen, X., Liu, X., Wang, L. et al. Expression of fibroblast activation protein in lung cancer and its correlation with tumor glucose metabolism and histopathology. Eur J Nucl Med Mol Imaging 49, 2938–2948 (202...
the proliferating fibroblasts were marked by the expression ofMKI67 FAP +成纤维细胞在肿瘤组织中显著富集,它的marker基因FAP、MMP1和MMP3通常与成纤维细胞活化和细胞外基质重塑相关。有趣的是,具有更多FAP +成纤维细胞浸润的 CRC 患者在 TCGA 和数据集 GSE17536 队列中表现出更短的 无进展生存期。
cancer stage(P < 0. 05). There was no correlation of FAP staining with tumorgrade. Conclusion:The expression of FAP in colorectal carcinoma is related with tumor aggressiveness and metasta-sis. Detection of FAP expression might be helpful in the evaluation of the prognostic factors in patients...
4. Chen, X., Liu, X., Wang, L. et al. Expression of fibroblast activation protein in lung cancer and its correlation with tumor glucose metabolism and histopathology. Eur J Nucl Med Mol Imaging 49, 2938–2948 (2022). https://doi....
Here we show that FAP expression is higher in advanced ovarian cancer and is only detected in invasive ovarian cancer cells. Silencing FAP induces apoptosis and FAP’s enzymatic activity is dispensable for cell survival. To elucidate the cause of apoptosis, we find that NF-κB activity is ...
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Sulda, M.L., Abbott, C.A., Hildebrandt, M. (2006). DPIV/CD26 and FAP in Cancer: A Tale of Contradictions. In: Lendeckel, U., Reinhold, D., Bank, U. (eds) Dipeptidyl Aminopeptidases. Advances in Experimental Medicine and Biology, vol 575. Springer, Boston, MA . https://doi....