FAP-2286是3B-Pharmaceuticals GmbH公司研发的含有环状七肽核心的靶向FAP的多肽。临床前评估显示,FAP-2286对FAP重组蛋白和成纤维细胞表面表达的FAP都表现出高度亲和力,并且比FAPI-46具有更长的肿瘤滞留和抑制时间。动物生物分布研究表明,68Ga-F...
Results: Forty-six patients were imaged with 68Ga-FAP-2286 PET. The highest average uptake was seen in sarcoma, cholangiocarcinoma, and colon cancer. The lowest uptake was found in lung cancer and testicular cancer. The average SUVmax was significantly higher on 68Ga-FAP-2286 PET than on ...
The fibroblast activation protein (FAP) is an emerging target for molecular imaging and therapy in cancer. OncoFAP is a novel small organic ligand for FAP
Fibroblast Activation Protein (FAP) is a membrane-bound serine protease whose expression is often elevated in activated fibroblasts associated with tissue remodeling in various common diseases such as cancer, arthritis and fibrosis. Like the closely related dipeptidyl peptidase DPPIV, the extracellular dom...
Results: Forty-six patients were imaged with 68Ga-FAP-2286 PET. The highest average uptake was seen in sarcoma, cholangiocarcinoma, and colon cancer. The lowest uptake was found in lung cancer and testicular cancer. The average SUVmax was significantly higher on 68Ga-FAP-2286 PET than on ...
Excluding 3 patients who did not receive a comparative 18F-FDG PET/CT scan, the remaining 16 patients (lung cancer, n = 8; appendiceal cancer, n = 1; colon cancer, n = 1; esophagus cancer, n = 1; gastric cancer, n = 1; head and neck cancer, n = 1; hepatic cancer, n = 1;...
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