Fibroblast activation protein (FAP) is not only specifically expressed in cancer-associated fibroblasts (CAFs) of most neoplastic diseases, but also highly expressed in some diseases characterized by tissue remodeling. FAP inhibitors (FAPIs) PET can target the distribution of FAP in tissues and organs...
Conclusions: This study showed the feasibility of 18F-FAPI-74 for the diagnosis of FAP-expressing pancreatic cancer. 18F-FAPI-74 showed higher uptake in the tumor xenograft model with FAP expression than 68Ga-FAPI-04, suggesting the advantage of higher detection rate as well as wide availability...
Lee, H.O., et al.,FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells. BMC Cancer, 2011. 11: p. 245. Nagaraju, C.K., et al.,Global fibroblast activation throughout the left ventricle but localized fibrosis ...
FAPα(+)胰腺星形细胞通过CXCL1介导Akt磷酸化促进胰腺癌侵袭转移(Fibroblast activation protein α-positive pancreatic stellate cells promote the migration and invasion of pancreatic cancer by CXCL1-mediated Akt phosphorylation) 内容亮点...
(A) Immunoblot analysis confirming FAP-alpha overexpression in 231-FAP and HT-1080-FAP cells. (B) Relative FAP-alpha mRNA expression levels (mean +- SD) of prostate cancer-associated fibroblasts (PCAFs), pancreatic cancer-associated fibroblasts (CAF35), MDA-MB-2... View More 已发表图片由...
Schizandrin A suppressed pancreatic cancer proliferation and cancer associated fibroblast activation via inhibiting the ... Author: Zhirui Zeng, et. al. Year: 2024 Journal: Front Oncol Applications: Unspecified Reactivity: Unspecified Title: Anlotinib inhibits cervical cancer cell proliferation and inva...
PTRT with177Lu-FAP-2286 appears to ameliorate symptoms in rapidly proliferating adenocarcinomas as noted by significant pain reduction in patient 4, with liver metastases; patient 6, with diffuse bone metastases; and patient ...
Exogenous FAP protein expression or FAP-overexpressing fibroblasts promoted cell proliferation and invasion in ovarian cancer and pancreatic cancer.8, 9 Several investigations have indicated that FAP is expressed in epithelium-derived tumor cells including breast cancer,10 pancreatic cancer,11 gastric cancer...
Colorectal cancer (CRC) is among the most common malignancies with limited treatments other than surgery. The tumor microenvironment (TME) profiling enables the discovery of potential therapeutic targets. Here, we profile 54,103 cells from tumor and adja
Department of Surgery and Gastroenterology, University of Verona, Verona, Italy Gian Gaetano Delaini Department of Surgery, Masaryk Memorial Cancer Institute, Brno, Czech Republic Tomáš Skřička Department of Surgery and Gastroenterology, University of Verona, Verona, Italy ...