9. Herraiz M, Barbesino G, Faquin W, et al. Prevalence of Thyroid Cancer in Familial Adenomatous Polyposis Syndrome and The Role of Screening Ultrasound Examinations. Clin Gastroenterol Hepatol. 2007;5(3):367-373. 10.张秋雷,江从庆,钱群.家族性腺瘤性息肉病的预防性外科治疗[J].中华结直肠疾病电...
The thyroid cancer (TC) cases account for 1–2% of FAP patients, and the risk of development of papillary carcinoma in a female polyposis patient is 100–160 times higher than in the background population. So far, there were described only eight FAP families, with more than one family ...
In this study, we aimed to investigate the safety and efficacy of the albumin binder-conjugated FAP-targeted radiopharmaceutical, 177Lu-EB-FAPI (177Lu-LNC1004), in patients with metastatic radioiodine-refractory thyroid cancer (mRAIR-TC). Patients and Methods:: This open-label, non-randomized, ...
- 《Cancer》 被引量: 450发表: 2001年 Genotype and phenotype of patients with both familial adenomatous polyposis and thyroid carcinoma. The incidence of thyroid carcinoma in familial adenomatous polyposis (FAP) is thought to be 1%-2%, with the majority of cases being female. We have investi....
- 《Cancer Letters》 被引量: 176发表: 1998年 Inhibition of histone deacetylase activity enhances Fas receptor-mediated apoptosis in leukemic lymphoblasts. FasL, Fas, FADD, RIP, caspase-8, caspase-3, Bid, FLIP(S+L), FLASH and FAP-1, proteins known to act within the Fas-apoptosis cascade,...
Post-partum thyroiditis is often asymptomatic, thus underdiagnosed and reflects chronic inflammation [3]. Breast parenchyma is characterized by low FAP expression in normal tissue, but high expres- sion in breast cancer [4, 5]. Furthermore, the density of breast and fibro-glandular tissue depends...
In addition, significantly reduced uptake in the critical organs (liver, colon) compared to [177Lu]Lu-DOTAGA.(SA.FAPi)2 was observed with [177Lu]Lu-DOTAGA.Glu.(FAPi)2 in a first patient study (medullary thyroid cancer) while maintaining high and prolonged tumor uptake. Rad...
Screening for thyroid cancer in patients with FAP is worthwhile.The article discusses a study on the role of routine neck ultrasonography in identifying asymptomatic thyroid cancer in patients with familial adenomatous polyposis (FAP).Greenhill
A first diagnostic application in cancer patients revealed high intratumoral uptake of both radiotracers already 10 min after administration but a higher uptake in oral mucosa, salivary glands, and thyroid for FAPI-21. Conclusion: Chemical modification of the FAPI framework enabled enhanced FAP binding...
56 A novel interplay between Ret oncoprotein and Fap-1 controls CD95-mediated apoptosis in medullary thyroid cancerdoi:10.1016/S1359-6349(10)71761-4V. Nicolini and G. Cassinelli and G. Cuccuru and I. Bongarzone and G. Petrangolini and M. Tortoreto and P. Mondellini and P. Casalini ...