参考来源: Avacta announces positive new data from the AVA6000 phase 1 trial demonstrating clinically meaningful tumor shrinkage in patients with salivary gland cancers. New Release. Avacta Therapeutics. January 16, 2025. Accessed January 17, 2025. A study evaluating the safety, pharmacokinetics and ...
The carcinoma cell expression pattern of FAP has been described in several types of cancers, but the role of FAP in oral squamous cell carcinoma (OSCC) is unknown. The role of endogenous FAP in epithelium-derived tumors and molecular mechanisms has also not been reported. In this study, FAP...
The first well-described and histologically corroborated case of familial adenomatous polyposis (FAP) was reported in 1881 in a 51-year-old Russian man (Bülow et al.2006). In the decades that followed, several cases were documented which demonstrated the genetic predisposition of developing FAP, ...
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This pr...
Furthermore, stromal expression of FAP is linked to immunosuppressive tumor microenvironment and poor prognosis in various cancers, suggesting a role in cancer progression and anti-tumor immunity4,5,6,7,8,19. Although the contribution of FAP in the development of these diseases is not well ...
7G). Recent studies have shown collaborative interactions between SPP1 + and FAP + cells in the immune microenvironments of liver and colorectal cancers, leading to ECM remodeling and the formation of a dense tumor microenvironment that can result in immune rejection32,35. Consistently, ...
Expression and Correlation of Multiple Tumor-suppressor Genes in Breast Cancers and Their Adjacent Hyperplastic Tissues; 乳腺癌及癌旁增生组织中多种抑癌基因表达比较及相关性研究 11. Testing Mutation of BRCA2 Gene in Familial Ovarian Cancer and Breast Cancer Tissues; ...
Comparison of the detection performance between FAP and FDG PET/CT in various cancers: a systemic review and meta-analysis[J]. Clin Nucl Med, 2023,48(2):132-142. DOI: 10.1097/RLU.0000000000004438 . 返回引文位置Google Scholar 百度学术 万方数据 [8] Chen BX , Xing HQ , Gong JN ,et ...
68Ga-FAPI PET/CT: Biodistribution and Preliminary Dosimetry Estimate of 2 DOTA-Containing FAP-Targeting Agents in Patients with Various Cancers FAPI-PET/CT: biodistribution and preliminary dosimetry estimate of two DOTA-containing FAP-targeting agents in patients with various cancers. J Nucl Med. .....
The carcinoma cell expression pattern of FAP has been described in several types of cancers, but the role of FAP in oral squamous cell carcinoma (OSCC) is unknown. The role of endogenous FAP in epithelium-derived tumors and molecular mechanisms has also not been reported. In this study, FAP...