Homozygous factor V Leiden mutationThoracic angioscanPulmonary embolism is a frequent and potentially serious pathology.The etiological assessment of pulmonary embolism is not carried out in a systematic way which makes the management not optimal with the possibility of repeated pulmonary embolism.Long-...
We found 36 patients homozygous for FVL. Patients homozygous for FVL were younger than controls at group level (56±18 vs. 63±17 展开 关键词: Homozygous factor V Leiden APC-resistance Thrombosis Venous thromboembolism Thrombophilia Heterozygous prothrombin mutation ...
Primary Budd–Chiari syndrome in a 3-year-old boy with homozygous factor V Leiden G1691A mutation Budd鈥揅hiari syndrome (BCS) is an uncommon disorder characterized by obstruction of hepatic venous outflow. The primary BCS is a rare disease with an inci... A Boskovic,I Kitic,I Stankovic…...
Resistance to activated protein C (APC) is a common inherited risk factor for venous thrombosis, which is associated with a mutation in coagulation factor V (factor V Leiden). We investigated the risk of venous thrombosis in individuals homozygous for this abnormality. We determined the factor V...
Kyung A. Kang
Factor V Leiden homozygous genotype and pregnancy outcomes. Obstet Gynecol 2009;114: 1249 –1253. 78. Prandoni P, Lensing AW, Cogo A, et al. The long-term clinical course of acute deep venous thrombosis. Ann Intern Med 1996;125:1–7. 79. Christiansen SC, Cannegieter SC, Koster T, ...
Homozygous carriers of factor V Leiden have an approximately 80-fold increased risk of venous thrombosis. Also double heterozygous carriers of both the fac... I Martinelli,C Legnani,P Bucciarelli,... - 《Thrombosis & Haemostasis》 被引量: 373发表: 2001年 The clinical outcome after inferior ven...
to distinguish heterozygotes from homozygotes. Patients on heparin therapy or with known lupus anticoagulant should proceed directly to molecular testing if the modified functional assay is not used. When relatives of individuals known to have factor V Leiden are tested, the DNA method is recommended...
Five patients (7.7%) were carriers for the homozygous form and thirty-two (49.2%) for the het- erozygous form. Factor V-Leiden was isolated in 19 patients and associated with prothrombin G 20210 A mutation in 4 patients and with other prothrombotic genetic mutations in 14 patients (MTHFR C...
The greatest increase in risk for VTE occurs when a family member is identified with homozygous FVL. In this situation, the current data indicate that the annual risk for an initial VTE event is approximately 18 times as high as for relatives who do not have a FVL mutation, translating into...