Heterozygosity for the factor V Leiden (G1691A) mutation predisposes renal transplant recipients to thrombotic complications and graft loss. Transplantation 2001; 72:549-50.Wuthrich RP;Cicvara-Muzar S; Booy C;.Heterozygosity for the factor V Leiden (G1691A) mutation predisposes renal tr...
Heterozygosity for the factor V Leiden (G1691A) mutation predisposes renal transplant recipients to thrombotic complications and graft loss. Heterozygosity for a mutation in the coagulation factor V gene (factor V Leiden; FVL) leads to resistance to activated protein C and represents the most co.....
Phenotypic homozygous activated protein C resistance associated with compound heterozygosity for Arg506Gln (factor V Leiden) and His1299Arg substitutions in factor V. Br J Haematol 1997; 99: 257–261. Article CAS Google Scholar Luddington R, Jackson A, Pannerselvam S, Brown K, Baglin T . ...
Overall, the probability of a successful pregnancy outcome is high, even in homozygous women.77 Pregnancy loss A large number of case-control studies found a high preva- lence of Factor V Leiden heterozygosity (up to 30%) in women with unexplained recurrent pregnancy loss, compared with 1–...
Methods: Newborns from 22 pregnant women with thrombophilia (Factor V Leiden (FVL), n=16; anticardiolipin antibodies, n= 3; lupus anticoagulant, n=1; protein C deficiency, n=1; prothrombin G20210A mutation, n=1) were enrolled into the study. All women were treated with low-molecular-...
HipertensiÓn intracraneal benigna y heterocigosis para el factor V de Leiden = Benign intracranial hypertension and heterozygosity for factor V Leiden mutationBenign idiopathic intracranial hypertension (BIH) in association with ... MA Perez,BM Cerezo,PJJ Garcia,... - 《Anales De Pediatria》 被...
Leiden) that not only renders FVa less susceptible to the proteolytic inactivation by APC but also impairs the anticoagulant properties of FV. This G1691A point mutation inF5results in an arginine to glutamine substitution at amino acid 506, the site where APC cleaves FVa.217Thefactor V Leiden...
2001).Compoundheterozygosityandhomozygosityformissensemutationsofcysteineresidues2739,2754,2804and2806havebeendescribedintype3VWD(Zhangetal,1994;Montgomeryetal,1999;P.Tjernberg,1G.Castaman,2H.L.Vos,1R.M.Bertina1andJ.C.J.Eikenboom11HaemostasisandThrombosisResearchCentre,DepartmentofHaematology,LeidenUniversity...
The decision regarding hormone replacement therapy in this lady was complicated due to the presence of Factor V Leiden heterozygosity. A brief discussion and review of the literature follow.KibbeyDepartment of EndocrinologyK.Department of EndocrinologyVincent...
January 2011 71 EGAPP Working Group Genetics IN Medicine • Volume 13, Number 1, January 2011 Table 3 Age-related relative risks for first lifetime venous thromboembolism (VTE) events in family members with and without Factor V Leiden (FVL) mutations FVL heterozygosity (no. patients) Present...