However, it was unclear whether TOX maintained TEX fate commitment and, thus, whether TOX removal would reprogram TEX into more functional CD8 lineages with enhanced capacity for tumor control. Methods Here, we used an adoptive T cell transfer approach in mice, which we infected with lymphocytic ...
Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade can reinvigorate TEX cells, but reinvigoration is not durable. A major unanswere
Nuclear ACSS2 overexpression or ACLY inhibition prevented TEX differentiation and enhanced tumor-specific T cell responses. These findings unveiled a nutrient-instructed histone code governing CD8 + T cell differentiation, with implications for metabolic- and epigenetic-based T cell therapies. 展开 ...
single immune cell data sets were used to identify marker gene sets for exhausted CD8 + T cells (CD8Tex) in breast cancer. Machine learning methods were used
TCF-1 is a key transcription factor in progenitor exhausted CD8 Tcells (Tex). Moreover, this Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. However, the role of the transcription factor TCF-1 in early fate decisions and initial generation of Tex cells is unclear. ...
Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade can reinvigorate TEX cells, but reinvigoration is not durable. A major unanswered question is whether TEX cells differentiate...
T cells doi:10.3389/fimmu.2024.1490845T-cell exhaustionIMMUNE responseGLUTATHIONE peroxidaseT cellsVIRUS diseasesDuring chronic infection or tumorigenesis, persistent antigen stimulation contributes to the exhaustion of CD8 T cells. Nevertheless, exhausted CD8 T (TEX) cells still...
Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies suc... MS Abdel-Hakeem,S Manne,JC Beltra,... - 《Nature Immunology》 被引量: 0发表: 0年 The epigene...
However, when antigens cannot be eliminated, such as in persistent infection and cancer, continuous antigen receptor stimulation drives an alternative differentiation trajectory, known as T cell exhaustion1,2,3. Exhausted T (Tex) cells are characterized phenotypically by the upregulation of co-inhibito...
These Texeff autoimmune cells may still drive β cell killing, differing from dysfunctional, fully exhausted CD8+ T cells observed in chronic viral infection and cancer.52,53,84,85,86,87,88,89,90,91,92 Furthermore, we identified an oxidative stress-related signature in intra-islet Texint ...