Pmp alignments showing examples of protein regions containing high concentration of FxxN motifs (purple), GGA(I, L) motifs (orange), and cysteine residues (blue).Alexandra NunesJoão P. GomesKaruna P. KarunakaranRobert C. Brunham
Protein pattern and profile databases contain information on motifs found in sequences. Sequence motifs correspond to structural or functional features in proteins. So, the use of protein sequence patterns or profiles is a valuable tool in determining the function of proteins. InterPro InterPro is a...
Motifs are simple combinations of secondary structure that occur in many different proteins and which carry out a similar function. An example is the helix-loop helix. It consists of two antiparallel helices at about a 60-degree angle to each other connected by a loop. This motif, which binds...
Explain how some DNA mutations cause no effect on the resulting protein, others alter the protein's function and still others cause the protein to stop functioning all together. Also, give an example of an original DNA sequence and two mutations of that ...
Helix-Turn-Helix DNA binding motifs found by the Gibbs sampling system. Compared to the CAP HTH logo there is much less sequence conservation within the DNA binding helix (11-17), as might be expected for a diverse sample of proteins. Edit Logo HTH Proteins Human Splice Sites These logos...
Core structure:is very similar in different types of ribosomes, although noticeably large differences exist in size. Ribosomal RNA organization:in tertiary structural motifs. The catalytic activity of the ribosomes:Carried out by the ribosomal RNA (rRNA). ...
only 12% of the cell-cycle genes were detected. The genes detected as periodically expressed were found to have a statistically significant overrepresentation of known cell-cycle regulated sequence motifs. One known sequence motif and 18 putative motifs, previously not associated with periodic expressio...
We prove that the BCM problem is NP-complete even for a very simple type #OMEGA#_1=2~sum - {#PHI#}, which is used, in practice, for describing protein motifs in the PROSITE database. We also show that the NP-completeness of the problem does not change for the type #OMEGA#_...
where ( α ( i ) , β ( i ) ) is good for π if π accepts α ( i ) and rejects β ( i ) We prove that the BCM problem is NP-complete even for a very simple type Ω 1 =2 ∑ {θ}, which is used, in practice, for describing protein motifs in the PROSITE database. ...
A second example deals with blood coagulation factors VII, IX and X and protein C, all featuring a common epidermal growth factor (EGF)-SP C-terminal assembly. Highly specific motifs are found at the connection between the CCP or EGF module and the activation peptide of the SP domain: [P...