I am using python to create a program that converts a set of DNA sequences into amino acid (protein) sequences. I then need to find a specific subsequence, and count the number of sequences in which this specific subsequence is present. This is the code I have s...
motifsa propertyLipids and several specialized proteins are thought to be able to sense the curvature of membranes (MC). Here we used quantitative fluorescence microscopy to measure curvature-selective binding of amphipathic motifs on single liposomes 50-700 nm in diameter. Our results revealed that ...
RNA molecules can fold into intricate shapes that can provide an additional layer of control of gene expression beyond that of their sequence. In this Review, we discuss the current mechanistic understanding of structures in 5′ untranslated regions (UTRs) of eukaryotic mRNAs and the emerging metho...
Hence, retroactivity should be considered in connection with circuit parts to optimize the behavior of IFFL circuits. Our observations of IFFLs led us to examine a few other motifs capable of sign-sensitive response acceleration. Comparing the behavior of IFFLs to that of negative autoregulation, ...
Binding of arrestin to phosphorylated G-protein-coupled receptors (GPCRs) controls many aspects of cell signaling. The number and arrangement of phosphates may vary substantially for a given GPCR, and different phosphorylation patterns trigger different arrestin-mediated effects. Here, we determine how ...
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Using BLAST, we identified 129 other sequences with high similarity to the AEP domain of PrimPol (PP-N190). We aligned them and visualised the conservation status of crucial residues and motifs described in previous reports (Fig.3a); their function is described further below. ...
TF motifs can be indicative of biological pathway regulation indicating when a gene is expressed. These findings of predicted TF can then be put into a gene ontology tool (PANTHER or DAVID) to assess how a candidate lncRNA is transcriptionally regulated. For instance, the presence of pioneering...
In the human brain the connectome could also loosely refer to a sequence of coactivated areas (presumably functionally connected areas), which are defined by fMRI resting-state signals and offer a more macroscopic view of stroke-related connectivity (Carter et al., 2012). The human macroscopic ...
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