Hsp90 is an essential molecular chaperone responsible for the folding and activation of hundreds of ‘client’ proteins, including the glucocorticoid receptor (GR). Previously, we revealed that Hsp70 and Hsp90 remodel the conformation of GR to regulate l
RNA molecules can fold into intricate shapes that can provide an additional layer of control of gene expression beyond that of their sequence. In this Review, we discuss the current mechanistic understanding of structures in 5′ untranslated regions (UTRs) of eukaryotic mRNAs and the emerging metho...
Laboratoire de Biome´trie et Biologie Evolutive, F-69622 Villeurbanne, France The production of genome sequences has led to another important advance in their annotation, which is closely linked to the exact determination of their content in terms of repeats, among which are transposable elements...
Systemic lupus erythematosus (SLE or lupus) is an immune-mediated disease associated with substantial medical burden. Notably, lupus exhibits a striking female bias, with women having significantly higher susceptibility compared to men, up to 14-fold higher in some ethnicities. Supernumerary X chromosom...
Current advanced deep-learning models have displayed an unprecedented level of comprehension and problem-solving ability, and have been used to predict gene structure, function and expression based on DNA or protein sequence, and prominently also their use in high-throughput phenomics in agriculture. ...
This de novo formation takes place even though traditional natural selection could not have acted on this sequence of mutations until the gene was already complete (substantial enough to be active), in clear contradiction with what Jacob justifiably predicted to be impossible [14]. Also challenging...
motifs in the required combination to target the sequence of interest.3Like ZFNs, TALENs are fusion proteins, relying on the Fok1 endonuclease to introduce a DSB at the target site but compared to ZFNs, are cheaper and produce faster results—they are more flexible to design as individual...
[单项选择题]Approximately how long will the course last 关键词: long course approximately A. A. Nine days. B. B. Two weeks. C. C. One month. 本题来源:2016年广东公共英语考试考前冲刺卷(8) 查看最佳答案和解析
g, GR protein sequence conservation mapped onto the GR atomic model from the GR:Hsp90:FKBP52 complex. Residue conservation is depicted from most variable (cyan) to most conserved residues (maroon). GR residues that interact with FKBP52 are shown as spheres. Source data Full size image In ...
For example, protein phosphorylation was found to regulate ZIP7 activity resulting in the release of Zn2+ from intracellular stores leading to phosphorylation of tyrosine kinases and activation of signaling pathways. In addition, sequence analyses predict all 24 human zinc transporters to be ...