Cell senescence, which is an irreversible state of cell proliferative arrest, has emerged as a potentially important contributor to tissue dysfunction and organismal ageing. Cell senescence is triggered by a variety of senescence stressors, which affect gene expression and multiple signalling pathways ...
MeCP2 mediated senescent EPC dysfunction through epigenetic regulation. 展开 关键词: Endothelial progenitor cells Senescence MeCP2 SIRT1 Epigenetic DOI: 10.1186/s13287-018-0828-y 被引量: 11 年份: 2018 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 Springer Springer (全网免费下载) 掌桥...
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic regulation is a heritable change in gene expressions independent of nucleotide sequence changes. As the common epigenetic regulation mechanisms, DNA methylation, histone modification, and non-coding RNA regulation have...
Epigenetic modification of chromatin plays an important role in the regulation of gene expression. DNA is methylated post-synthetically on cytosine residues predominantly in the sequence CpG andin vitromethylated promoters are known to be generally inactive when transfected into eukaryotic cells [2]. DNA...
Critical role of histone demethylase Jmjd3 in the regulation of CD4(+) T-cell differentiation Epigenetic factors have been implicated in the regulation of CD4+ T cell differentiation. Jmjd3 plays a role in many biological processes, but its in vivo ... Q Li,J Zou,M Wang,... - 《Nature...
Thus, here we present a non-equilibrium thermodynamic continuum model of the meso-scale chromatin organization in the nucleus to bridge the gap in the understanding of the mechanistic relation between transcriptional and epigenetic regulation and the size-scaling of the meso-scale heterochromatin domains...
This leads to p16INK4a down regulation, which in turn involves CR induced longevity. In line with the above, DNA methylation pathway may strongly tend to control key cancer-related genes during CR. This indicates a close relationship between aging and cancer (Li and Tollefsbol, 2011).As ...
Stem cell senescence in diabetes: forgetting the sweet old memories. Epigenetics may be defined as a heritable phenotype that does not depend on the primary sequence of DNA. This trait may involve its heritability through ... D Cesselli,AP Beltrami - 《Diabetes》 被引量: 4发表: 2014年 ...
et al. Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation. Cell 156, 663–677 (2014). This paper provided a link between reprogramming and oncogenic transformation, showing that transient expression of reprogramming factors in an in vivo ...
(NHEJ) which operates mostly in the pre-replicative G1 phase of the cell cycle and is the most prominent form of DNA repair mechanism in terminally differentiated cells. When the damage is irreparable, cells respond with cell cycle arrest, apoptosis, senescence, or several other cell mechanisms...