Eosinophil-derived neurotoxin (EDN) has been proposed as a potential biomarker for asthma in children. A recent study found that serum EDN levels at 1 year were significantly different between asthmatic and non-atopic children at 3 years, suggesting that EDN could be used as an early dia...
Asthma is a chronic inflammatory airway disease in which neutrophils and eosinophils play an important role [1,2]. Activated neutrophils can release granules through degranulation, internalize and degrade pathogens through phagocytosis, and release neutrophil extracellular traps (NETs) to defend against ext...
Nucala in asthma patients stratified by eosinophil levels
Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease Nasal IL13 expression levels were 3.9-fold higher in asthmatic participants who experienced an asthma exacerbation in the past year (P = .01). ... A Poole,C Urbanek,C Eng,... - 《J Allergy Clin Immu...
High levels of eosinophil cationic protein in wheezing infants predict the development of asthma We investigated whether, in infants experiencing their first episode of wheezing, eosinophil activation is present and can predict the development of asthma. ... D Koller,C Wojnarowski,K Herkner,... - ...
Studies have shown that serum EOS levels in adults do not change with age but are susceptible to factors such as asthma, smoking, COPD, metabolic syndrome, and obesity, thus affecting serum EOS stability [19]. Serum EOS levels are associated with serum infections, dermatosis, allergic diseases,...
Journal of Asthma ResearchGursel G,Turktas H,Gokcora N et al.Comparison of sputum and serum eosinophil cationic protein (ECP) levels in nonatopic asthma and chronic obstructive pulmonary disease. Journal of Asthma . 1997Cursel G,Turktas H,Gokcora N,et al.Comparison of sputum and serum eos...
in allergic asthma models. In human subjects and mice, eosinophils stain positive for IL-5Rα, CCR3, Siglec-8 (human)/Siglec-F (mice), EMR1 (human)/F4/80 (mice), and CD11b and are characterized by a high side scatter (SSC) in flow cytometry. ...
Eosinophil cationic protein (ECP), a cytotoxic protein contained in the granules of eosinophils, has been suggested as having an important role in the pathogenesis of asthma. To determine whether ECP plays a similar role in bronchiolitis, we tested samples of nasopharyngeal secretions, obtained from...
Peak flows were monitored in 15 children. The data suggest that serum ECP levels were higher in acutely ill asthmatics than in stable state. With successful therapy for asthma, serum ECP levels were mostly decreased. However, rising ECP values after treatment may suggest unsatisfactory results ...