In 15 patient hospitalized for asthma, MBP levels of sputum were markedly elevated. Treatment with bronchodilators and glucocorticoids caused an increase peak expiratory flow rate, a reduction in blood eosinophils, and a decrease in the serum and sputum levels of MBP. The results indicate that ...
Biopsy specimens of lesional skin showed dermal infiltration of lymphocytes and eosinophils with deposition of eosinophil granule major basic protein in the ... C Wolf,H Pehamberger,S Breyer,... - 《Journal of the American Academy of Dermatology》 被引量: 99发表: 1989年 Development and applicati...
Conclusion Simultaneously elevated Fe NO and B‐Eos related to reduced lung function in asthmatics, wheezing symptoms, but not to a history of asthma attacks. Asthma attacks and ER ‐visit due to asthma were related to increased B‐Eos levels. 展开 关键词: asthma eosinophils epidemiology ...
Seven volunteers served as controls: five healthy subjects and two allergic volunteers (one asthmatic and one rhinitic).Results: The patient's eosinophils had defective chemotaxis, shape changes, and F-actin reorganization against eotaxin, when compared to the controls. CCR3 surface and total ...
ECP is a paralog of EDN in humans, and they share 70% similarity at the protein level. They are both secreted by activated eosinophils during pathogenic stimulation and inflammatory processes [37]. In patients with asthma, the serum level of ECP is elevated and serves as a clinical biomarker...
The quantities of IL-13 mRNA reflected the numbers of EG2+ eosinophils per unit area of submucosa in the biopsy specimens as determined by immunohistochemistry, which were statistically equivalent in the atopic and nonatopic subjects with asthma and significantly elevated as compared with those in ...
Elevated numbers of blood eosinophils are a risk factor for asthma exacerbations. Reslizumab is a humanised anti-interleukin 5 monoclonal antibody that disrupts eosinophil maturation and promotes programmed cell death. We aimed to assess the efficacy and safety of reslizumab in patients with inadequa...
1998 / Accepted: January 23, 1999 Abstract The NOA (Naruto Research Institute Otsuka Atrichia) mouse, an animal model of allergic or atopic dermatitis, exhibits ulcerative skin lesions associated with accumulation of mast cells and eosinophils, a significantly increased level of serum IgE, and scratc...
Eosinophils. Effective in destroying parasites and cancer cells. Basophils. Secrete histamine and react to allergens in the body. What is Considered High or Elevated White Blood Cell Count? Dr. Hina Naushad, a hematopathologist from Creighton Medical Center, says that an elevated WBC count is when...
NP has been known to be a Th2-skewed eosinophilic inflammation in the nasal sinus mucosa. T helper type 2-associated cytokines IL-4, IL-5 and IL-13 are involved in the pathogenesis of the eosinophilic airway diseases such as allergic asthma, allergic rhinitis and NP [37,38]. IL-25, IL...