More recently, eosinophils have been demonstrated to participate in host defense against respiratory viruses. The specific contributions of eosinophils to the pathophysiology of asthma remains controversial. However, the balance of evidence indicates that they have a significant role in the disease, ...
Eosinophils are the specific kind of white blood cell, involved in the pathophysiology of several inflammatory and malignant disorders as well as innate immunity. They contribute to the innate immune response by secreting highly cytotoxic proteins from their secretory granules in opposition to bacteria, ...
Nasal polyps are the common end-point of a number of conditions characterised by inflammation and are rarely 'curable' in its true sense. After considerati... L Badia,V Lund - 《Drugs》 被引量: 249发表: 2001年 Airway dysfunction in nasal polyposis: a spectrum of asthmatic disease? Backgr...
Likewise, eosinophils are clearly recruited to and activated in lung tissue as part of the pathophysiology of asthma, and most current evidence suggests that eosinophils contribute to airway dysfunction and tissue remodelling in this disorder8,9. Evolution tells us that the ability to induce pathology...
in skin diseases [4], eosinophilic esophagitis [36], and asthma [37]. TGF-β, which can either be released by eosinophils or by epithelial cells upon stimulation with IL-4 and IL-13, was shown to activate fibroblasts resulting in the secretion of matrix proteins, as well as the release ...
Bronchial asthma is not a homogenous disease. Several variants of asthma can be distinguished. One of them is aspirin-induced asthma. In this distinct clin... G Bochenek,K Banska,Z Szabo,... - Current Drug Targets - Inflammation & Allergy 被引量: 24发表: 2002年 The Study of the Remodeli...
The role of the mast cell in the pathophysiology of asthma - ScienceDirect There is compelling evidence that human mast cells contribute to the pathophysiology of asthma. Mast cells, but not T cells or eosinophils, localize within... Peter,Bradding,and,... - 《Journal of Allergy & Clinical...
Eosinophils play a role in maintaining health,which includes regulating the immune system, regenerating and repairing tissue, and host protection (eg, defending the body against parasitic infection).1In severe asthma, however, too many eosinophils are a key driver of asthma pathophysiology, including ...
While eosinophils participate in diseases that are related to type 2 immune activation, like asthma16,17, several studies also highlighted the homeostatic functions of eosinophils. The presence of a homeostatic subset of eosinophils has been unveiled in various tissues, such as the bone marrow, the...
Eosinophils are regarded by many as fundamental to the pathophysiology of allergic diseases, including asthma. An improved understanding of the mechanisms involved in these responses is therefore of great relevance to asthma pathogenesis and the development of new therapeutics. Most therapies that are eff...