Recent clinical trials of eosinophil-blocking agents have utilized a blood eosinophil count of 300 or 400 eosinophils/mm 3 or higher to identify subjects with moderate to severe asthma. We observed multiple instances of counts which varied widely in the same patient within the same day. Objectives...
In eosinophilic asthma an increased eosinophil cell count in peripheral blood is the gold standard for determination of the pheno-/endotype and severity of disease. Despite a broad consensus there is concern on validity of this simple measurement, because the eosinophil compartment is far from ...
Blood eosinophil count, Forced Expiratory Volume in 1 second, % of predicted (FEV1%), Fractional exhaled nitric oxide (FeNO), Asthma Control Test (ACT), oral steroid (OCS) intake and exacerbation rate were evaluated during mepolizumab treatment. Results: 69 patients were enrolled (mean age: ...
Diagnosis: Hypereosinophilia has generally been defined as a peripheral blood eosinophil count greater than 1,500/mm3 and may be associated with tissue ... Jason,Gotlib - 《American Journal of Hematology》 被引量: 281发表: 2012年 Eosinophilic disorders: Molecular pathogenesis, new classification, an...
Eosinophil unit conversion calculator Convert your patient’s lab results to an absolute blood eosinophil count in cells/µL. Get absolute EOS counts PATIENT TYPES WHO MAY BENEFIT FROM NUCALA In your practice, you may know these types of patients with severe eosinophilic asthma (SEA). ...
The entire esophagus is involved; proximal eosinophil count may be higher than distal; eosinophils may be patchy in distribution Gender and Age Distribution ■ Occurs in all age groups but is more common in the children and young adults ■ Men are more frequently affected than women Clinical Feat...
The evidence that eosinophilic COPD constitutes a distinct subset of COPD remains unclear. In contrast to asthma, where the immunologic mechanisms of atopic disease and eosinophilia coalesce with an increasing eosinophil count and poorly controlled asthma, there is relatively little rationale for eosinophil...
Additionally, in the phase IIa clinical study "Dupilumab in Persistent Asthma with Ele- vated Eosinophil Levels," adverse events were reported by comparable proportions of patients in both groups (77% in the placebo group versus 81% in the dupilumab group) [13]. The phase 2b Pathway study ...
Implication of fraction of exhaled nitric oxide and blood eosinophil count in severe asthma 2018, Allergology International Citation Excerpt : In fact, mean sputum eosinophil ratio was approximately 8% in this study (Table 3). Therefore, patients with low FeNO/high b-EOS may potentially be under...
BackgroundAn inverse relationship between oral corticosteroid (OCS) dose and peripheral blood eosinophil (PBE) count is widely recognized in patients with severe eosinophilic asthma; however, there are limited data available to quantify this relationship. This post hoc analysis of the SIRIUS study ()...