In recent studies, patients with severe, uncontrolled asthma and high eosinophil counts respond to biologic therapies targeting the type-2 signaling pathway and eosinophils themselves (eg, anti-IL-5 therapy). New treatments that address the pathophysiology of asthma offer a promising alternative to ...
Asthma is a chronic and heterogeneous disease, which is defined as severe disease whenever it requires treatment with a high dose of inhaled corticosteroids plus a second controller and/or systemic corticosteroids to prevent it from becoming ''uncontrolled" or if it remains ''uncontrolled" despite ...
The relationship of elevated blood eosinophils to this process needs study. To determine whether a high blood eosinophil countis a risk factor for future asthma exacerbations in adult persistentasthma. By using electronic pharmacy and health care data from Kaiser Permanente Southern California, 2392 ...
50 Furthermore, exposure to high levels of endotoxin in the home, such as occurs in farmhouses, is associated with reduced rates of allergy and an enhanced number of interferon-producing cells in peripheral blood.51,52 Collectively, these studies suggest that exposure to microbes may have a ...
Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (TH2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by ...
The growing appreciation of asthma as a heterogeneous disease has led to the concept that asthma consists of multiple, different phenotypes, but now the challenge is to link underlying biology to phenotypes to allow a more robust classification and under
asthmaCD34+ progenitor cellsChurg-StrausseosinophilshypereosinophiliaIL-5Breast cancer is the most common cancer in women in the U.S. and Western Europe ... Ho-Suk Oh - 《Allergy》 被引量: 81发表: 2012年 Clinical management of eosinophilic gastrointestinal disorders Author information: (1)Laborato...
Sputum and blood eosinophils during corticosteroid treatment of acute exacerbations of asthma Eleven patients with chronic bronchial asthma were studied during a noninfectious exacerbation. Each patient received 80 mg of prednisone daily for three days. Spirometric values, total blood eosinophil counts, and...
et al. Persisting remodeling and less airway wall eosinophil activation in complete remission of asthma. Am. J. Respir. Crit. Care Med. 183, 310–316 (2011). Article PubMed Google Scholar Volbeda, F. et al. Can AMP induce sputum eosinophils, even in subjects with complete asthma ...
Sputum induced eosinophils counts as well as eosinophil peroxidase dosage were higher in severe asthmatic patients as compared to the healthy controls (p<0.001 and p=0.01, respectively). Otherwise, despite of the high dose and the continuous treatment with prednisone the cells count did not change...