their biological relevance often remains elusive, especially in pathophysiological contexts such as cancer. In this study, we find that the tumor marker CD166/ALCAM (Activated LeukocyteCellAdhesionMolecule) is a clathrin-independent cargo. We show that endophilin-A3—but neither A1 nor A2 isoforms—f...
Heike JgerCellular Physiology and BiochemistryJanbein M, Abo Quader M, Hoppner AC, Gruner I, Wanker E, Walter S, Kuppers E, Grissmer S, Jager H (2014). Evidence for the Interaction of Endophilin A3 with Endogenous KCa2.3 Channels in PC12 Cells. Cell Physiol Biochem 34:474-490....
We show that a membrane curvature-sensing protein, endophilin A3, promotes growth and migration of colon cancer cells through two competing mechanisms: an endocytosis pathway that is required for proliferation and a GTPase regulatory pathway that controls cell motility. EndoA3 stimulates cell migration ...