最近国内外研究提示endophilin -A1在多种认知功能损害性疾病,如阿尔茨海默病(AD)和糖尿病认知功能损害中异常表达.Endophilin -A1是一种广泛表达于脑的突触前神经终末的胞浆蛋白,在突触囊泡的内吞回收,尤其是网格蛋白介导的囊泡内吞(CMVE)过程中起重要作用.研究认为其本 身可能调节Aβ的生成,也可能通过CMVE来...
关键词:Endophilin-A1;突触囊泡;网格蛋白介导的内吞;认知损害众所周知,为了保证神经冲动信号持续、有效地传递,负责递质转运的囊泡需快速地回收到突触膜,等待释放,将突触前的电信号转为化学信号传到突触后膜。递质回收实质是一种细胞内吞作用,神经细胞自有一套特殊而有效的突触复合物装置来完成这一囊泡回收过程。网格...
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; EEN-B1; EEN-B1bA335L15.1 (SH3-domain GRB2-like 2); Endophilin A1; Endophilin-1; endophilin-A1; FLJ20276; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2; SH3D2A; SH3D2AEndophilin A1 BAR domain; SH3-domain GRB2-like 2; SH3GL2; SH3P4; SH3P4endophilin-1...
糖尿病大鼠海马endophilin-A1和dynamin-1的表达研究
Together, these results reveal a novel function of postsynaptic endophilin A1 in spine morphogenesis, stabilization and synaptic function through the regulation of p140Cap. Keywords: endophilin A1; p140Cap; spine morphogenesis; actin cytoskeleton; synapse formation Cell Research (2015) 25:496-516. ...
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中文名称:SH3GL2/Endophilin A1 中文同义词:胞吞蛋白ENDOPHILIN 1抗体 英文名称:SH3GL2/Endophilin A1 英文同义词:SH3GL2/Endophilin A1 CAS号: 分子式: 分子量:0 EINECS号: 信息错误报告 您的Email: 按国家浏览SH3GL2/Endophilin A1国外供应商中国供应商 ...
We have characterized mammalian endophilin B1, a novel member of the endophilins and a representative of their B subgroup. The endophilins B show the same domain organization as the endophilins A, which contain an N-terminal domain responsible for lipid binding and lysophosphatidic acid acyl transf...
Endophilin A1 (EP) is a protein enriched in synaptic terminals that has been linked to Alzheimer's disease (AD). Previous in vitro studies have shown that EP can bind to a variety of proteins, which elicit changes in synaptic transmission of neurotransmitters and spine formation. Additionally, ...