Endophilin-A1是一种广泛表达于脑的突触前神经终末的胞浆蛋白,在突触囊泡的内吞回收,尤其是网格蛋 白介导的囊泡内吞(CMVE)过程中起重要作用。研究认为其本身可能调节Aβ的生成,也可能通过CMVE来影响脑内Aβ 的生成与释放,提示其与AD的发病有关。此外,endophilin-A1在糖尿病认知功能损害的大鼠脑内表达下调。
endophilinsynaptic vesicleendocytosissynaptotagminSynaptic vesicle (SV) endocytosis is a critical and well-regulated process for the maintenance of neurotransmission. We previously reported that synaptotagmin-11 (Syt11), an essential non-Ca2+-binding Syt associated with brain diseas...
糖尿病大鼠海马endophilin-A1和dynamin-1的表达研究
Together, these results reveal a novel function of postsynaptic endophilin A1 in spine morphogenesis, stabilization and synaptic function through the regulation of p140Cap. Keywords: endophilin A1; p140Cap; spine morphogenesis; actin cytoskeleton; synapse formation Cell Research (2015) 25:496-516. ...
Endophilin A1 (EP) is a protein enriched in synaptic terminals that has been linked to Alzheimer’s disease (AD). Previous in vitro studies have shown that EP can bind to a variety of proteins, which elicit changes in synaptic transmission of neurotransm
SH3GL2/Endophilin A1 基本信息更多信息 中文名称: SH3GL2/Endophilin A1 中文同义词: 胞吞蛋白ENDOPHILIN 1抗体 英文名称: SH3GL2/Endophilin A1 英文同义词: SH3GL2/Endophilin A1 CAS号: 分子式: 分子量: 0 EINECS号: Mol文件: Mol File SH3GL2/Endophilin A1 信息错误报告 提交 ...
retrolinkin and endophilin A1的抗体。to 表示是，或者与之相对应。
We have characterized mammalian endophilin B1, a novel member of the endophilins and a representative of their B subgroup. The endophilins B show the same domain organization as the endophilins A, which contain an N-terminal domain responsible for lipid binding and lysophosphatidic acid acyl transf...
Endophilin-A1Dynamin-1认知功能损害目的研究糖尿病大鼠海马组织 endophilin-A1和dynamin-1的表达,以期进一步研究其与糖尿病认知功能损害的关系.方法 14只雄性SD大鼠随机分为两组:正常对照(NC)组和糖尿病(DM)组.腹腔注射链脲佐菌素55mg.kg-1制备糖尿病模型,5周后断头取材,分别进 行如下实验:①Western Blot法检测...
Together, these data suggest that the specificity for ultrafast endocytosis is defined by the phosphorylation-regulated interaction of Endophilin A1 with the C-terminal extension of Dyn1xA.doi:10.1038/s44318-024-00145-xYuuta ImotoJing XueLin Luo...