认知损害最近国内外研究提示endophilin -A1在多种认知功能损害性疾病,如阿尔茨海默病(AD)和糖尿病认知功能损害中异常表达.Endophilin -A1是一种广泛表达于脑的突触前神经终末的胞浆蛋白,在突触囊泡的内吞回收,尤其是网格蛋白介导的囊泡内吞(CMVE)过程中起重要作用.研究认为其本 身可能调节Aβ的生成,也可能通过...
Endophilin-A1是一种广泛表达于脑的突触前神经终末的胞浆蛋白,在突触囊泡的内吞回收,尤其是网格蛋白介导的囊泡内吞(CMVE)过程中起重要作用。研究认为其本身可能调节Aβ的生成,也可能通过CMVE来影响脑内Aβ的生成与释放,提示其与AD的发病有关。此外,endophilin-A1在糖尿病认知功能损害的大鼠脑内表达下调。本文就...
英文名称: Anti-SH3GL2/Endophilin A1 总访问: 308 国产/进口: 国产 半年访问: 28 产地/品牌: Bioss/博奥森 产品类别: 抗体 规格: 100ul 200ul 最后更新: 2024-10-9 货号: bs-19754R CAS 号: 参考报价: 100ul/1280 200ul/1980 立即询价 电话咨询 ...
英文名称:SH3GL2/Endophilin A1抗体 中文名称胞吞蛋白Endophilin 1抗体 别名bA335L15.1 (SH3 domain GRB2 like 2); CNSA2; EEN B1; EEN-B1; Endophilin 1; Endophilin A1; Endophilin A1 BAR domain; Endophilin-1; Endophilin-A1; FLJ20276; FLJ25015; OTTHUMP00000021084; SH3 domain containing GRB2 ...
Endophilin A1的主要功能是通过促进神经元内吞作用来调节神经元连接,它在突触地点表达也较为广泛。但是Endophilin A2和A3的功能存在很大争议,它们是否参与神经元内吞以及突触囊泡膜的内吞还没有明确的研究结果。因此,我们需要进行更进一步的研究来探讨Endophilin A2和A3在神经元内吞和突触囊泡膜内吞中的作用。 目的:...
Endophilin A1 is a monomer in the cytosol, it will homodimerize and heterodimerize with endophilin-2 when active at the synapse. Endophilin A1 is also associated with endocytic trafficking of growth factor receptors. In concert with CIN85, Cbl and ataxin-2, Endophilin A1 extend the half-life ...
Together, these results reveal a novel function of postsynaptic endophilin A1 in spine morphogenesis, stabilization and synaptic function through the regulation of p140Cap. Keywords: endophilin A1; p140Cap; spine morphogenesis; actin cytoskeleton; synapse formation Cell Research (2015) 25:496-516. ...
糖尿病大鼠海马endophilin-A1和dynamin-1的表达研究
Endophilin A1 (EP) is a protein enriched in synaptic terminals that has been linked to Alzheimer's disease (AD). Previous in vitro studies have shown that EP can bind to a variety of proteins, which elicit changes in synaptic transmission of neurotransmitters and spine formation. Additionally, ...
Protein Name: Endophilin-A1 Human Gene Id: 6456 Swiss-Prot: Q99962 Formulation: Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide Source: Rabbit Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Conce...