CELL populationsCD4 antigenCYTOTOXIC T cellsINTERLEUKIN-9Circulating CD4CD8double-positive (DP) T cells are associated with a variety of disease states. However, unlike conventional T cells, the composition of this population is poorly understood. Here, we used single-cell RNA sequencing (scRNA-seq...
The molecular markers CD4 and CD8—defining helper T cells and killer T cells, respectively—were once considered mutually exclusive. But "double positive" CD4+-CD8+ T cells have lately been discovered in people in various states of health. In a May study published in theJournal of Experimental...
Even though the expression of CD4 and CD8 on thymocytesis considered mutually exclusive, CD4+ CD8+ double-positive T cells (DP) represent a small subset of T lymphocytes that have been described in the peripheral blood of normal individuals, as well as in some pathological conditions. In partic...
Thymocytes displaying self-reactive T cell receptors usually undergo negative selection in the thymus. Here we demonstrate that agonist peptides can promote positive selection of immature double-positive thymocytes into distinct lineages, varying with the agonist concentration and the animal's age. Microar...
Double Positive Thymocytes Select Mucosal-Associated Invariant T Cells. During thymic development, NKTs are selected by CD1dexpressing cortical thymocytes; however, the hematopoietic cell type responsible for MAIT cell selection ... Seach,Natalie,Guerri,... - 《Journal of Immunology》 被引量: 73发表...
简介scRNA-seq数据解释被称为双链的技术产物所混淆,即代表多个细胞的单细胞转录组数据。此外,scRNA-seq细胞通量被有目的地限制,以最小化双偶体形成率。通过识别与模拟双链具有相同表达特征的细胞,DoubletFind…
We identified 29 immune cell subsets in the CD45+ and CD3+ compartments. Double positive T cells and PD‐1 positive CD4 T cells were expanded and nave CD4 T cells were decreased in the bone marrow of patients with newly diagnosed/progressing POEMS. These findings provide evidence for possible...
Natural Treg cells constitute an independent thymus-derived T-cell lineage whose developmental program in humans is still ill-defined. Here, we provide evidence of a Treg-cell differentiation pathway at the double positive (DP) stage, prior to commitment to the CD4+ or CD8+ lineage, in ...
Acute thymic atrophy has also been observed in sepsis and is characterized by the specific loss of CD4+CD8+ double-positive thymocytes, thus resulting in a dramatic reduction in T-cell development and immunosuppression12,13. It is well known that thymic atrophy is caused by microbial infection-...
Dicentric chromosomes are unstable as they can be broken during cytokinesis when they are pulled apart by each daughter cell and form a bridge. Asymmetric breakage results in an inverted duplication, the degree of which depends on the location of the break. In budding yeast, breakage occurs eithe...